川崎病发生机制研究  

The pathogenesis of Kawasaki disease

作　　者：牛超[1] 王琳琳 贾尝 褚茂平[1] Niu Chao;Wang Linlin;Jia Chang;Chu Maoping(The Second Affiliated Hospital and Yuying Children′s Hospital of Wenzhou Medical University,Wenzhou 325027,China)

机构地区：[1]温州医科大学附属第二医院育英儿童医院,温州325027

出　　处：《中国小儿急救医学》2020年第9期645-649,共5页Chinese Pediatric Emergency Medicine

摘　　要：川崎病是一种急性全身性中小血管炎性综合征,是儿童后天性心脏病的主要原因,最易累及冠状动脉,可以导致如冠状动脉扩张、冠状动脉瘤和急性心肌梗死等严重并发症。目前关于川崎病的发病原因及致病机制尚无准确定论,本文将围绕传染性病原体、环境因素、免疫失调和遗传倾向等方面阐述川崎病的病因,并围绕免疫系统异常活化、炎性细胞因子表达上调、金属基质蛋白酶活性提高、血管内皮损伤/血管内皮功能紊乱等方面综述川崎病的致病机制。Kawasaki disease is an acute systemic vascular inflammatory syndrome,which is the main cause of acquired heart disease in children.It is most likely to cause serious complications such as coronary artery dilation,coronary artery aneurysm,and acute myocardial infarction.At present,there is no accurate conclusion about the etiology and pathogenic mechanism of Kawasaki disease.We performed this review to realize the etiology of Kawasaki disease regarding infectious pathogens,environmental factors,immune disorders and genetic tendencies.Meanwhile,this study will focus on the abnormal activation of the immune system,the up-regulated expression of inflammatory cytokines,the increased activity of metal matrix proteinases(MMPs),and vascular endothelial injury/vascular endothelial dysfunction to review the pathogenic mechanism of Kawasaki disease.

关 键 词：川崎病 发病机制 血管内皮损伤 冠状动脉病变 

分 类 号：R725.4[医药卫生—儿科]