针对活体光声内窥成像的三维血管增强算法  

Algorithm for Three-Dimensional Enhancement of Blood Vessels in Photoacoustic Endoscopic In Vivo Imaging

作　　者：李超 孙明健[1,2] 马立勇[1] 沈毅[2] 林日强[3] 龚小竞[3] Li Chao;Sun Mingjian;Ma Liyong;Shen Yi;Lin Riqiang;Gong Xiaojing(School of Information Science and Engineering,Harbin Institute of Technology(Weihai),Weihai,Shandong264209,China;School of Astronautics,Harbin Institute of Technology,Harbin,Heilongjiang150001,China;Research Lab for Biomedical Optics and Molecular Imaging,Shenzhen Institutes of Advanced Technology,Chinese Academy of Science,Shenzhen,Guangdong518055,China)

机构地区：[1]哈尔滨工业大学(威海)信息科学与工程学院,山东威海264209 [2]哈尔滨工业大学航天学院,黑龙江哈尔滨150001 [3]中国科学院深圳先进技术研究院生物医学光学与分子影像研究室,广东深圳518055

出　　处：《中国激光》2020年第9期280-289,共10页Chinese Journal of Lasers

基　　金：国家重点研发计划(2017YFE0121000,2018YFC0114800);中国科学院威高计划[2017]011号;山东省自然科学基金(ZR2017MF041);山东省重点研发计划(2018GGX103047);深圳市科技计划(JCYJ20160608214524052);深圳市工程实验室项目(介入式诊疗一体化关键技术与工程实验室)。

摘　　要：消化道肿瘤是最常见的肿瘤疾病之一。新兴的光声成像技术可以敏锐地捕捉肿瘤周围滋养血管的信息,有助于临床进行更精准的诊断。匹配的血管增强算法可以有效突出图像中的血管网络,但光声活体内窥成像的探测角度有限,易造成明显的血管形态异常,现有方法很难实现有效的血管增强。采用自研的光声内窥系统对大鼠直肠进行活体成像,针对活体成像结果提出了一种融合结构和强度两个层面信息的三维血管增强算法,并采用该算法对结直肠血管图像进行了增强。结果表明:所提算法可以有效提升增强效果,抑制机械抖动带来的边缘毛刺,在活体状态下获取了高质量的结直肠三维血管图像,说明其在基础医学研究和临床应用中具有一定的潜在价值。Gastrointestinal tumors are one of the most common types of tumors. Emerging photoacoustic imaging technology can sharply capture the information of the nourishing blood vessels surrounding the tumors, which may give potential contributions to accurate clinical diagnosis. The matched vessel enhancement algorithm can effectively highlight the vessel network. However, the detection angle of in vivo photoacoustic endoscopic imaging is limited, which results in obvious vascular structure abnormalities. It is difficult for current enhancement algorithms to effectively enhance blood vessels. Therefore, a three-dimensional vascular enhancement algorithm was developed in this investigation that fuses the information on structure and intensity of the colorectal vessel of rats, based on a self-designed endoscopic photoacoustic imaging system. The results indicate that this algorithm can effectively improve the imaging effect, suppress edge burrs brought about by mechanical vibration, and obtain in vivo high-quality three-dimensional images of the colorectal vessel, indicating that it has potential value in basic medical research and clinical applications.

关 键 词：医用光学 内窥成像 光声成像 血管增强 三维增强 

分 类 号：Q631[生物学—生物物理学]