基于太赫兹光谱的DNA检测及应用综述  

Review of DNA Detection and Application Based on THz Spectroscopy

作　　者：王馨达 宋正勋[1,2,3] 李岩 冯思镒 郎百和 王作斌[1,2,3] Wang Xinda;Song Zhengxun;Li Yan;Feng Siyi;Lang Baihe;Wang Zuobin(School of Electronic Information Engineering,Changchun University of Science and Technology,Changchun,Jilin 130022,China;International Research Centre for Nano Handling and Manufacturing of China,Changchun,Jilin 130022,China;Overseas Expertise Introduction Project for Discipline Innovation,Changchun,Jilin 130022,China)

机构地区：[1]长春理工大学电子信息工程学院,吉林长春130022 [2]国家纳米操纵与制造国际联合研究中心,吉林长春130022 [3]教育部学科创新引智基地,吉林长春130022

出　　处：《激光与光电子学进展》2020年第17期34-42,共9页Laser & Optoelectronics Progress

基　　金：欧盟地平线计划(734174);国家重点研发计划政府间国际科技创新合作重点专项(2017YFE0112100);高等学校学科创新引智计划(D17017)。

摘　　要：太赫兹波辐射因具备特有的感测能力以及无创和非电离特性而备受关注。DNA分子间的振动模式(扭转、集体振动、氢键和骨架振动)大多处于太赫兹波段。相比红外波段,DNA在太赫兹波段表现出了很多独特的吸收特性。系统地分析了太赫兹时域光谱技术在DNA分子领域的研究进展,阐述了单个碱基、碱基对、DNA的鉴定与识别,以及它们的吸收光谱和振动模式;此外,还介绍了太赫兹波的生物安全性及其潜在应用;最后根据当前的研究现状,归纳了DNA分子在太赫兹光谱研究方面仍然存在的问题,为今后的相关研究提供参考。Terahertz radiation has received considerable attention owing to its unique sensing ability and its noninvasive and nonionized properties.The intermolecular vibration modes of DNA(torsion,collective vibration,hydrogen bonding,and skeleton vibration)are mostly in terahertz band.DNA in the terahertz band has more unique absorption characteristics than that in the infrared band.The research progress of terahertz time-domain spectroscopy(THz-TDS)technology in the field of DNA is systematically analyzed.The identification of single base,basepair,DNA and their absorption spectrum and vibration modes are described.Furthermore,the biosafety and potential applications of terahertz band are described.Finally,in view of the current research situation,the existing problems are summarized,which will provide a reference for future research.

关 键 词：光谱学 太赫兹 DNA 碱基 振动模式 生物安全 

分 类 号：O133[理学—数学]