流式细胞术分析嗜碱性粒细胞活化试验在过敏性疾病中的应用  

Application of flow cytometry analyzing basophil activation test in allergy disease

作　　者：李宜凡(综述) 刘长山(审校)[1] Li Yifan;Liu Changshan(Department of Pediatrics,the Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院儿科,300211

出　　处：《国际儿科学杂志》2020年第9期607-611,共5页International Journal of Pediatrics

基　　金：天津市卫生行业重点攻关项目(16KGl16)。

摘　　要：过敏性疾病是影响人们健康和生活质量的常见疾病。随着流式细胞术的发展,嗜碱性粒细胞活化试验(basophil activation test,BAT)作为一种体外激活试验,已成为诊断血清特异性免疫球蛋白E(specific immunoglobulin E,sIgE)介导的过敏性疾病的一种新型方法。将BAT标准化,并将其应用于临床实践及过敏机制的探索这一过程非常重要。该文就BAT的主要原理及其在过敏性疾病诊治方面的应用进行综述。Allergic disease is the common disease that affects human health and life quality.With the development of flow cytometry,basophil activation test(BAT),as an ex vivo challenge test,has become a new method in the diagnosis of allergic disease that IgE mediates.An important step is to establish a standardized BAT method in order to make it available in clinical applications and to explore the mechanisms of allergy in laboratory.This review focuses on the main principles,clinical utility in the diagnosis and management of allergic disease.

关 键 词：流式细胞术 嗜碱性粒细胞活化试验 过敏性疾病 

分 类 号：R33[医药卫生—人体生理学]