双胎妊娠胎儿染色体异常产前筛查与诊断流程探讨  

Study on prenatal screening and diagnosis of chromosomal abnormalities in fetuses with twin pregnancies

作　　者：白艳玲 郑梅玲[1] BAI Yanling;ZHENG Meiling(The First Hospital of Shanxi Medical University,Shanxi Taiyuan 030002,China)

机构地区：[1]山西医科大学第一医院,山西太原030002

出　　处：《中国妇幼健康研究》2020年第10期1355-1358,共4页Chinese Journal of Woman and Child Health Research

摘　　要：随着辅助生殖技术的广泛应用及女性生育年龄的推迟,双胎妊娠及胎儿染色体非整倍体异常的发生率逐年增加。双胎妊娠的染色体疾病产前筛查主要依靠孕早期超声及孕中期血清学筛查。孕妇外周血胎儿游离DNA产前筛查技术在临床的应用,使得双胎妊娠的染色体疾病产前筛查效率也逐渐提高。该文就双胎妊娠胎儿的多种染色体疾病产前筛查方法进行综述,总结出双胎妊娠在孕早期、孕中期的合理产前筛查方案,为双胎妊娠的产前筛查临床工作提供参考。With the widespread application of assisted reproductive technology and the postponement of women’s childbearing age,the incidence of twin pregnancy and fetal chromosome aneuploid abnormality is increasing year by year.Prenatal screening of chromosome diseases in twin pregnancy mainly relies on ultrasound in the first pregnancy and serological screening in the second trimester.With the application of prenatal screening technology of free DNA in peripheral blood of pregnant women in the clinic,the efficiency of prenatal screening of chromosome diseases in twin pregnancy has been gradually improved.In this paper,the methods of prenatal screening for multiple chromosomal diseases in fetuses with twin pregnancy were reviewed,and the reasonable prenatal screening programs in the first and second trimester of twin pregnancy were summarized,to provide a reference for the clinical work of prenatal screening for twin pregnancy.

关 键 词：双胎 非整倍体 产前筛查 孕妇外周血胎儿游离DNA 无创DNA 

分 类 号：R714.5[医药卫生—妇产科学]