宫颈癌病原微生物检测及预防措施  

Detection and precautionary measures of pathogenic microorganisms in patients with cervical cancer

作　　者：徐书方[1] 刘立秋 张玉清[1] 张艳 孙月菊[1] 范星[1] 苗莉娜[1] 李娟 XU Shufang;LIU Liqiu;ZHANG Yuqing(Shijiazhuang Medical High-class Special School,Hebei,Shijiazhuang 050599,China;不详)

机构地区：[1]石家庄医学高等专科学校,石家庄市050599 [2]河北省卫生健康委员会综合监督执法局,石家庄市050000 [3]河北医科大学第四医院 [4]河北省石家庄市井陉矿区医院

出　　处：《河北医药》2020年第21期3230-3233,共4页Hebei Medical Journal

基　　金：河北省医学科学研究重点课题计划(编号:20191506)。

摘　　要：目的探讨已婚女性阴道微生物生物群落构成与宫颈癌发生的关系,并为该病的有效预防提供指导。方法采用回顾性分析方法,选取2015年10月至2017年10月收治的300例宫颈癌患者作为研究对象,按病理分型分为鳞癌组228例和腺癌组72例。采集患者宫颈和阴道部位拭子,比较人乳头瘤病毒(human papillomavirus,HPV)和单纯疱疹病毒2型(herpes simplex virus 2,HSV-2)感染率及HPV分型感染率。结果宫颈鳞癌组患者HPV阳性检出率为94.30%,宫颈腺癌组患者HPV阳性检出率为73.61%,差异有统计学意义(χ^2=24.576,P<0.05);宫颈鳞癌组患者HSV-2感染率为77.63%,宫颈腺癌组患者HSV-2感染率为38.89%,差异有统计学意义(χ^2=37.957,P<0.05);宫颈鳞癌组患者混合感染率为70.61%,宫颈腺癌组患者混合感染率为36.11%,差异有统计学意义(χ^2=27.745,P<0.05);宫颈鳞癌组与宫颈腺癌组患者混合感染发生率均低于单一感染发生率,差异有统计学意义(P<0.05)。宫颈鳞癌中,感染的6种高危型HPV型别分别为16(62.72%)、18(21.05%)、52(6.58%)、58(4.83%)、33(3.07%)、31(1.75%);宫颈腺癌中,检出的主要型别是高危型HPV 18(45.83%)、16(31.94%)、52(9.72%)、58(5.56%)、33(4.17%)、31(2.78%)。结论HPV16、18及HSV-2与宫颈癌的发生密切相关。Objective To investigate the correlation between the composition of vaginal microflora in married women and the occurrence of cervical cancer,and to provide guidance for the effective prevention of cervical cancer.Methods A total of 300 patients with cervical cancer who were admitted and treated in our hospital from October 2015 to October 2017 were enrolled in the study,who were divided into squamous carcinoma group(n=228)and adenocarcinoma group(n=72)according to pathological classification.The infection rates and human papillomavirus(HPV)and herpes simplex virus 2(HSV 2)as well as HPV typing infection rate were observed and compared between the two groups.Results There were significant differences in HPV positive detection rates between squamous carcinoma group and adenocarcinoma group(94.30%vs 73.61%,P<0.05).Moreove there were significant differences in HSV2 infection rates between squamous carcinoma group and adenocarcinoma group(77.63%vs 38.89%,P<0.05).In addition there were significant difference in the mixed infection rates between squamous carcinoma group and adenocarcinoma group(70.61%vs 36.11%,P<0.05).The incidence rate of mixed infection in both groups were significantly lower than those of single infection(P<0.05).In cervical squamous cell carcinoma,the six high risk HPV types of infection were HPV 16(62.72%),18(21.05%),52(6.58%),58(4.83%),33(3.07%),31(1.75%),and in cervical adenocarcinoma,the main types detected were HPV 18(45.83%),16(31.94%),52(9.72%),58(5.56%),33(4.17%),31(2.78%).Conclusion The HPV 16,18 and HSV2 are closely related to the occurrence of cervical cancer.

关 键 词：宫颈癌 人乳头瘤病毒 单纯疱疹病毒2型 预防措施 

分 类 号：R195[医药卫生—卫生统计学]