子痫前期患者血清VEGF、IL-18、MCP-1水平及与血液流变学指标关系  

Serum VEGF,IL-18,MCP-1 levels of patients with preeclampsia and their relationship with hemorheology indicators

作　　者：王娜[1] 王英[2] 万里新[3] 吴佩蔚 兰岚[1] 姚利 张小环 李松[5] WANG Na;WANG Ying;WAN Lixin;WU Peiwei;LAN Lan;YAO Li;ZHANG Xiaohuan;LI Song(Department of Obstetrics,Nanyang Central Hospital Affiliated to Zhengzhou University,Nanyang,Henan,China,473000;Department of Gynecology,Nanyang Central Hospital Affiliated to Zhengzhou University,Nanyang,Henan,China,473000;Department of Oncology,Nanyang Central Hospital Affiliated to Zhengzhou University,Nanyang,Henan,China,473000;Department of Reproductive Medicine,Nanyang Central Hospital Affiliated to Zhengzhou University,Nanyang,Henan,China,473000)

机构地区：[1]郑州大学附属南阳市中心医院产二科,河南南阳473000 [2]郑州大学附属南阳市中心医院妇三科,河南南阳473000 [3]郑州大学附属南阳市中心医院肿瘤科,河南南阳473000 [4]郑州大学附属南阳市中心医院生殖医学科,河南南阳473000 [5]郑州大学附属南阳市中心医院妇二科,河南南阳473000

出　　处：《分子诊断与治疗杂志》2020年第10期1303-1306,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(192102310368)。

摘　　要：目的分析子痫前期(PE)患者血清VEGF、IL-18、MCP-1水平及与血液流变学指标关系。方法分析本院于2017年2月至2020年2月临床确诊的118例PE患者临床资料,根据其病情分为PE轻度组63例、PE重度组55例。同时选取60例同时间段进行检查的正常妊娠孕妇作为对照组,观察3组人群血清VEGF、IL-18、MCP-1水平及血液流变学指标水平,分析其相关性。结果PE重度组患者血清血管内皮生长因子(VEGF)、白细胞介素18(IL-18)、单核细胞趋化蛋白-1(MCP-1)水平明显高于PE轻度组及对照组,差异具有统计学意义(P<0.05);PE重度组患者花生四烯酸诱导的血小板最大聚集率(AA)、红细胞压积(HCT)、D-二聚体(D-D)水平显著高于PE轻度组及对照组,AA、HCT、D-D随病情严重程度增加而升高,差异具有统计学意义(P<0.05);相关性分析显示AA、HCT、D-D、VECG、IL-18、MCP-1之间均为正相关(P<0.05)。结论子痫前期患者随着病情进展,血清VEGF、IL-18、MCP-1水平上升,VEGF、IL-18、MCP-1与血液流变学指标为正相关性,可作为子痫前期患者病情判断的预测指标。Objective To analyze the serum VEGF,IL-18,and MCP-1 levels of patients with preeclampsia(PE)and their relationship with hemorheology indicators.Methods The clinical data of 118 patients with preeclampsia who were diagnosed in this hospital from February 2017 to February 2020 were retrospectively analyzed.According to their condition,patients were divided into the mild PE group,63 cases,and the severe PE group,55 cases.At the same time,60 normal pregnant women who were examined were selected as the control group.The levels of serum VEGF,IL-18,MCP-1 and hemorheology indicators were observed in the three groups,and their correlation was analyzed.Results Serum vascular endothelial growth factor(VEGF),interleukin 18(IL-18),monocyte chemoattractant protein-1(MCP-1)levels of patients in the severe PE group were significantly higher than those in the mild PE group and the control group(P<0.05).The levels of arachidonic acid-induced maximum platelet aggregation rate(AA),hematocrit(HCT),and D-dimer(DD)of patients in the severe PE group were significantly higher than those in the mild PE group and the control group.The levels of AA,HCT and D-D increased with the severity of the disease,and the difference was statistically significant(P<0.05).Correlation analysis showed that AA,HCT,D-D,VECG,IL-18 and MCP-1 were all positively correlated(P<0.05).Conclusion As the disease progresses in patients with preeclampsia,serum VEGF,IL-18,MCP-1 levels increase.VEGF,IL-18,MCP-1 and hemorheological indicators are positively correlated,which can be used to judge the condition of patients with preeclampsia Predictive indicators.

关 键 词：子痫前期 血液流变学指标 单核细胞趋化蛋白-1 血管内皮生长因子 白细胞介素18 

分 类 号：R714.244[医药卫生—妇产科学]