血清25-羟基维生素D、IL-17水平与糖尿病视网膜病变的关系分析  

Analysis of the relationship between serum 25-hydroxyvitamin D,IL-17 levels and diabetic retinopathy

作　　者：孙晓菲[1] 范慧洁[1] 田勇[1] SUN Xiaofei;FAN Huijie;TIAN Yong(Department of Endocrinology,Zhengzhou People's Hospital,Zhengzhou,Henan,China,450000)

机构地区：[1]郑州人民医院内分泌科,河南郑州450000

出　　处：《分子诊断与治疗杂志》2020年第10期1349-1352,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(2018020817)。

摘　　要：目的探讨血清25-羟基维生素D(25-OHD)、白介素-17(IL-17)水平与糖尿病视网膜病变(DR)的关系。方法选取2018年1月至2019年12月间收治的348例糖尿病(DM)患者作为研究对象,根据眼底检查结果分为糖尿病视网膜病变组(DR组,n=140)和无糖尿病视网膜病变组(NDR组,n=208)。比较DR组和NDR组患者疾病相关指标[糖化血红蛋白(HbA1C)、低密度脂蛋白(LDL-C)、收缩压(SBP)、超氧化物歧化酶(SOD)]及25-OHD、IL-17水平,采用Spearman分析法分析DR组患者病情严重程度与25-OHD、IL-17水平的相关性,采用Pearson分析分析25-OHD、IL-17与DR组患者疾病相关指标的相关性,采用logistics回归分析DR发生的影响因素。结果DR组HbA1C、LDL-C、SBP、IL-17均高于NDR组,SOD、25-OHD水平均低于NDR组,差异具有统计学意义(P<0.05);Spearman相关性分析显示DR患者病情分期与25-OHD呈负相关关系(P<0.05),与IL-17水平呈正相关关系(P<0.05);Pearman相关性分析显示25-OHD与HbA1C、SBP呈负相关关系(P<0.05),与SOD呈正相关关系(P<0.05),与LDL-C不相关(P>0.05);IL-17与HbA1C、LDL-C、SBP呈正相关关系,与SOD呈负相关关系(P<0.05);logistics回归分析显示,IL-17是影响DR发生的危险因素(P<0.05),SOD是影响DR发生的保护因素(P<0.05)。结论25-OHD、IL-17与DR发生进展密切相关,监测DM患者两指标水平有一定临床价值。Objective To explore the relationship between levels of serum 25-hydroxyvitamin D(25-OHD)and interleukin-17(IL-17)and diabetic retinopathy(DR).Methods 348 patients with diabetes mellitus(DM)admitted between January 2018 and December 2019 were selected for this study.According to the results of fundus examination,they were divided into the diabetic retinopathy group(DR group,n=140)and the non-diabetic retinopathy group(NDR group,n=208).The levels of disease-related indicators[glycosylated hemoglobin(HbA1 C),low-density lipoprotein cholesterol(LDL-C),systolic blood pressure(SBP),superoxide dismutase(SOD)]and 25-OHD and IL-17 were compared between the DR group and the NDR group.Spearman analysis was used to analyze the correlation between disease severity and levels of 25-OHD and IL-17 in the DR group.Pearson analysis was used to analyze the correlation between 25-OHD,IL-17 and disease-related indicators in the DR group,and logistics regression analysis was used to analyze the influencing factors of DR occurrence.Results The levels of HbA1 C,LDL-C,SBP and IL-17 in the DR group were higher than those in the NDR group(P<0.05),while the levels of SOD and 25-OHD in the DR group were lower than those in the NDR group(P<0.05).Spearman correlation analysis showed the disease staging of DR patients was negatively correlated with 25-OHD(P<0.05),positively correlated with IL-17 level(P<0.05).Pearman correlation analysis showed that 25-OHD was negatively correlated with HbA1 C and SBP(P<0.05)and positively correlated with SOD(P<0.05),and not correlated with LDL-C(P>0.05).IL-17 was positively correlated with HbA1 C,LDL-C and SBP(P<0.05)and negatively correlated with SOD(P<0.05).Logistics regression analysis showed that IL-17 was a risk factor affecting DR(P<0.05),and SOD was a protective factor affecting DR(P<0.05).Conclusion 25-OHD and IL-17 are closely related to the occurrence and progression of DR.Monitoring the two indicators of DM patients has certain clinical value.

关 键 词：糖尿病视网膜病变 血清25-羟基维生素D 白介素-17 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]