先天性甲状腺功能减低症患儿IGF-1、IGFBP-3及Hcy水平变化及临床意义  

Changes and clinical significance of IGF-1,IGFBP-3 and Hcy levels in children with congenital hypothyroidism

作　　者：唐容华[1] 李琴[1] 陈晓蓉[1] 唐忠俊 TANG Ronghua;LI Qin;CHEN Xiaorong;TANG Zhongjun(Department of Pediatrics,Suining Central Hospital,Suining,Sichuan,China,629000)

机构地区：[1]遂宁市中心医院儿科,四川遂宁629000

出　　处：《分子诊断与治疗杂志》2020年第10期1380-1383,1387,共5页Journal of Molecular Diagnostics and Therapy

基　　金：四川省卫生和计划生育委员会科研课题(19PJ516)。

摘　　要：目的研究先天性甲状腺功能减低症(CH)患儿胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白(IGFBP-3)及同型半胱氨酸(Hcy)水平变化及其与生长发育的关系。方法选取本院2017年7月至2020年7月收治的90例CH患儿的临床资料为研究组;同期选取85例健康儿童为对照组,测量两组儿童身高、体重、智商等,评估其生长发育情况;采用免疫放射分析法、荧光偏振免疫法检测两组血清IGF-1、IGFBP-3及Hcy水平,分析其与生长发育的相关性。结果两组儿童年龄、出生体重、爬行月龄、独走月龄、萌牙月龄、身高、体重指数(BMI)比较差异均无统计学意义(P>0.05)。研究组儿童语言智商、操作智商、总智商显著低于对照组,差异具有统计学意义(P<0.05);在顺背与倒背项目中,研究组儿童背出数字显著低于对照组,差异具有统计学意义(P<0.05);IGF-1、IGFBP-3水平亦显著低于对照组,Hcy水平显著高于对照组,差异均具有统计学意义(P<0.05)。结论IGF-1、IGFBP-3及Hcy水平与儿童智商、身高及体重具有一定相关性;CH患儿经早期诊治,其生长发育可恢复正常水平。Objective To study the changes in levels of insulin-like growth factor-1(IGF-1),insulin-like growth factor binding protein(IGFBP-3)and homocysteine(Hcy)in children with congenital hypothyroidism(CH)and its correlation with growth and development.Methods The clinical data of 90 CH children admitted to this hospital from July 2017 to July 2020 were selected as the study group.85 healthy children were selected as the control group during the same period.The height,weight,IQ,etc.of the two groups of children were measured to assess their growth and development status.Immunoradioassay and fluorescence polarization immunoassay were used to detect serum IGF-1,IGFBP-3 and Hcy levels in the two groups and analyze the correlation with growth and development.Results There was no statistically significant difference between the two groups in age,birth weight,months of crawling,months of walking alone,months of teething,height,and body mass index(BMI)(P>0.05).The language IQ,operational IQ,and total IQ of the children in the study group were significantly lower than those in the control group and the difference was statistically significant(P<0.05).In the recitation forward and backward,the number recited by children in the study group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).The levels of IGF-1 and IGFBP-3 were significantly lower than those of the control group,and the level of Hcy was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusions The levels of IGF-1,IGFBP-3 and Hcy have a certain correlation with children s IQ,height and weight.Children with CH can return to normal levels after early diagnosis and treatment.

关 键 词：先天性甲状腺功能减低症 胰岛素样生长因子结合蛋白 胰岛素样生长因子-1 同型半胱氨酸 

分 类 号：R725.8[医药卫生—儿科]