急性心梗后心功能预后与血尿酸及肌酸肌酶同工酶水平的相关性  

Correlation between the prognosis of cardiac function and serum uric acid and CK-MB levels after acute myocardial infarction

作　　者：胡超勇 邹华伟 高鹏芝 HU Chaoyong;ZOU Huawei;GAO Pengzhi(Department of Cardiology,Taihe County People's Hospital,Fuyang,Anhui,China,236600;Department of Cardiology,Fuyang Hospital of Anhui Medical University,Fuyang,Anhui,China,236000)

机构地区：[1]安徽省阜阳市太和县人民医院心血管内科,安徽阜阳236600 [2]安徽医科大学附属阜阳医院心血管内科,安徽阜阳236000

出　　处：《分子诊断与治疗杂志》2020年第10期1415-1418,共4页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省科技计划项目(12010402c193)。

摘　　要：目的探讨急性心梗后心功能预后与血尿酸(SUA)及肌酸肌酶同工酶(CK-MB)水平的关系。方法选取2018年1月至2019年12月于本科室住院的急性心肌梗死患者173例,分别对患者进行SUA及CK-MB检测,评估患者舒张末期左心室内径(LVEDd),收缩末期左心室内径(LVEDs),左室射血分数(LVEF)和Gensini冠状动脉病变积分,根据是否患有高尿酸血症分组进行对比。结果两组患者的一般临床资料均衡可比,差异无统计学意义(P>0.05);合并高尿酸血症的心肌梗死患者的CK-MB峰值水平较其他患者明显升高(P<0.05),且出现峰值的时间更早;不同心功能Killip分级的患者SUA值与CK-MB峰值不同,差异有统计学意义(P<0.05),Killip分级越高的患者,SUA值与CK-MB峰值越高;ST段抬高型心梗(STEMI)患者SUA值与CK-MB峰值较非ST段抬高型心梗(NSTEMI)患者水平显著升高,差异有统计学意义(P<0.05);急性心肌梗死患者的SUA值与CK-MB峰值水平与LVEF呈负相关;与LVEDs、LVEDd、Gensini积分呈正相关;差异有统计学意义(P<0.05)。结论可以通过SUA及CK-MB值间接评估急性心肌梗死患者的心功能及预后。Objective To explore the relationship between the prognosis of cardiac function and the level of serum uric acid and CK-MB after acute myocardial infarction.Methods 173 patients with acute myocardial infarction who were hospitalized in our department from January 2018 to December 2019 were selected.All patients were tested for blood uric acid and CK-MB,and the patients were assessed for enddiastolic left ventricular diameter(LVEDd),end-systolic left ventricular diameter(LVEDs),left ventricular ejection fraction(LVEF),and Gensini coronary artery disease score,depending on whether they had the hyperuricemia group was compared.Results The general clinical data of the two groups of patients were balanced and comparable,and the difference was not statistically significant(P>0.05).The peak level of CKMB in patients with myocardial infarction combined with hyperuricemia was significantly higher than that of other patients(P<0.05).The peak time is earlier;the SUA value of patients with different cardiac function Killip grades is different from the peak CK-MB,and the difference is statistically significant(P<0.05).The higher the Killip grade,the higher the SUA value and the peak CK-MB.The levels of SUA and CK-MB peak in patients with ST-segment elevation myocardial infarction(STEMI)were significantly higher than those in patients with non-ST-segment elevation myocardial infarction(NSTEMI)(P<0.05)The SUA value of patients with acute myocardial infarction was negatively correlated with the peak level of CK-MB and LVEF;it was positively correlated with LVEDs,LVEDd,and Gensini score;the difference was statistically significant(P<0.05).Conclusion The cardiac function and prognosis of patients with acute myocardial infarction can be assessed indirectly through SUA and CK-MB values.

关 键 词：急性心肌梗死 心功能 血尿酸 肌酸激酶同工酶 

分 类 号：R542.22[医药卫生—心血管疾病]