特异性免疫治疗与支气管哮喘患儿肺功能水平影响的相关性研究  

Study on the relationship between specific immunotherapy and pulmonary function in children with asthma

作　　者：张义[2] 杨勤 靳蓉[2] 王菲[2] 刘燕[2] 吴静[2] 严化琼 朱珠[2] Zhang Yi;Yang Qin;Jin Rong;Wang Fei;Liu Yan;Wu Jing;Yuan Huaqiong;Zhu Zhu(Department of Physiopathology,Basic Medical College of Guizhou Medical University,Guiyang 550002,Guizhou,China;Department of Respiratory,Guiyang,City Maternal and Child Care Service Hospital,Guiyang 550003,Guizhou,China)

机构地区：[1]贵州医科大学基础医学院病理生理学教研室,贵州贵阳550002 [2]贵阳市妇幼保健院儿童呼吸科,贵州贵阳550003

出　　处：《贵州医药》2020年第9期1360-1363,共4页Guizhou Medical Journal

摘　　要：目的探讨特异性免疫治疗对支气管哮喘患儿肺功能水平的影响,分析其对改善支气管哮嚙患儿气道功能方面的疗效。方法依据《儿童支气管哮喘诊断与防治指南2016版》制定的纳入与排除标准,选取2017年2月至2018年4月贵州省贵阳市妇幼保健院儿童呼吸哮喘专科收治的60例支气管哮喘忠儿作为研究对象,采用随机数字表分为实验组和对照组,各30例。对照组30例患儿接受常规糖皮质激素吸入剂等基础用药治疗:实验组在基础用药治疗的同时给子特异性免疫(specifc immunotherapy,SIT)治疗。运用德国Jaeger公司MasterScreen肺功能仪分别于治疗前、治疗3个月、6个月、9个月及1年后检测并对比两组患儿.肺功能变化,观察两组患儿肺换气及通气功能的改善情况。结果治疗前两组患儿第-秒最大呼吸容积(Forced expiratory volume in one second,FEV1)、呼气峰值流速(Peak expioratoryflow,PEF)、呼出50%肺活量时最大呼气流量(Forced expiratory flow at 50%of FVC,FEF50)、呼出75%肺活量时最大呼气流量(Forced expiatory flow at 75%ofFVC,FEF75).最大呼气中期流量(Maximum mild-expiratory flow,MMEF)指标比较差异无统计学意义(P>0.05),治疗3个月、6个月、9个月及1年后分别进行定期检测结果显示,实验组名肺功能相关指标(FEV1、PEF,FEF50、FEF75、MMEF)在时间、组间、交互作用与对照组的对比差异均有统计学意义(P<0.05)。两组患儿上述肺功能指标均随治疗时间的延长显著改善:除实验组在治疗9个月与1年后肺功能指标(PEF、FEF50、FEF75、MMEF指标)均基本相近,差异无统计学意义(P>0.05),两组在其余相同治疗时间里,在本组内各肺功能指标对比差异均有统计学意义(P<0.05)。实验组患儿肺功能指标改善显著高于对照组,差异有统计学意义(P<0.05)。两组小气道指标(FEF50、FEF75、MMEF)治疗前两组间无明显差异,治疗后实验组较对照组明显改善,且不流计学意�Objective To explore the effect of specific immunotherapy on the pulmonary function of children with bronchial asthma and analyze its effect on improving the airway function of children with bronchial asthma.Methods According to the inclusion and exclusion criteria set out in the 2016 edition of the guidelines for the diagnosis and prevention of bronchial asthma in children,From February 2017 to April 2018,60 children with bronchial asthma were selected as the research objects who was from Guiyang maternal and child health hospital children's respiratory asthma specialty.Sixty children with bronchial asthma were selected and randomly divided into experimental group and control group with 30 cases each.The control group was given basic medication.The experimental group was given specific immunotherapy at the same time of basic medication treatment.Using master screen pulmonary function instrument of Jaeger company in Germany,before treatment,3 months,6 months,9 months and 1 year after treatment,the changes of pulmonary function in the two groups were detected and compared,and the improvement of pulmonary ventilation and ventilation function in the two groups were observed.Results Specific immunotherapy is helpful to improve the pulmonary function and reduce the chronic airway inflammation of children with asthma:Two groups of children before treatment,The Forced expiratory volume in one second(FEV1),Peak expioratory flow(PEF),Forced expiratory flow at 50%of FVC(FEF50),Forced expiratory flow at 75%of FVC(FEF75),?Maximum mild-expiratory flow(MMEF).There were no statistical significantly differences in the level comparison(P>0.05),3 months after treatment,6 months after treatment,9 months after treatment,1 year after treatment.Regular test results were displayed respectively,Lung function related indexes in experimental group(FEV1,PEF,FEF50,FEF75,MMEF)IN the time,Between two groups,Interaction compared with the control group,There were statistical significantly differences(P<0.05).The above lung function indexes of t

关 键 词：儿童 特异性免疫治疗 支气管哮喘 肺功能 

分 类 号：R562[医药卫生—呼吸系统]