478例药品不良反应报告分析  

Analysis of 478 Adverse Drug Reactions in a Hospital

作　　者：陈耀升 韩红玉[2] 王娟[1] 赵保红 CHEN Yaosheng;HAN Hongyu;WANG Juan;ZHAO Baohong(Zhengzhou Hospital Affiliated to Jinan University/Zhengzhou Second Hospital,Henan Zhengzhou 450000,China;The First Affiliated Hospital of Henan University o f Traditional Chinese Medicine,Henan Zhengzhou 450000,China)

机构地区：[1]暨南大学附属郑州医院/郑州市第二人民医院,郑州450000 [2]河南中医药大学第一附属医院,郑州450000

出　　处：《中国药物滥用防治杂志》2020年第5期297-301,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:了解某院药品不良反应的发生特点及影响因素,为临床合理用药提供参考。方法:对478例药品不良反应的患者性别与年龄分布、给药途径、药品种类,以及不良反应累及系统-器官及临床表现、不良反应的类别及转归情况进行回顾性分析。结果:478例药品不良反应报告中男性214例(44.77%)、女性264例(55.23%),50岁以上老年人发生不良反应率较高(58.58%);静脉滴注不良反应发生率最高278例(58.16%);抗感染类药物发生不良反应数较多106例(22.18%),中药注射剂次之70例(14.64%);不良反应主要累及系统-器官是皮肤及其附件损害136例(28.45%),其次为胃肠道反应69例(14.44%)、神经系统损害64例(13.39%);94.77%的不良反应在患者停药或经过抗过敏等治疗后能好转及痊愈,但有5.23%会导致病情延长、加重,多为抗感染药物的停药及更换。结论:应加强对药品不良反应的监管,掌握其规律及特点、反馈临床,加强临床用药监护,确保临床安全用药、合理用药。Objective:To investigate the characteristics and influencing factors of adverse drug reactions (ADR),and to provide references for rational drug use in clinic.Methods:The distribution of sex and age,route of administration,types of drugs,system-organ involvement and clinical manifestations,types of adverse reactions and outcomes of 478 patients with adrs were analyzed retrospectively.Results:Among the 478 ADR cases,214 cases (44.77%) were male and 264 cases(55.23%) were female.The incidence of adverse reactions was higher in the elderly aged 50 (58.58%),and the rate of ADR in intravenous administration was the highest 278 cases (58.16%).The adverse reactions of anti-infective drugs were more in 106 cases (22.18%) than that of traditional Chinese medicine injection in 70 cases (14.64%).The main adverse reactions were systemic-organ damage in 136 cases (28.45%),gastrointestinal reaction 69 cases (14.44%) and nervous system damage 64 cases (13.39%).94.77% of the adverse reactions improved and recovered after drug withdrawal or antiallergic treatment,but 5.23% of the cases were prolonged and aggravated,mainly for the anti-infective drug discontinuation and replacement.Conclusion:We should strengthen the supervision of adverse drug reactions,master its law and characteristics,feedback clinical,strengthen clinical drug monitoring,to ensure clinical safety and rational drug use.

关 键 词：药品不良反应 用药监护 安全用药 合理用药 

分 类 号：R95[医药卫生—药学]