润燥止痒胶囊对银屑病样皮损大鼠肠道菌群和炎症反应的影响  

Effects of Runzao Zhiyang capsule on gut microbiota and inflammatory response in rats with psoriatic lesions

作　　者：胡辉莹 胡银霞 刘昌顺[2] 苏小婷 戴辉 HU Hui-ying;HU Yin-xia;LIU Chang-shun;SU Xiao-ting;DAI Hui(General Hospital of Southern Theatre Command,People's Liberation Army of China,Guangzhou 510510,China;School of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,China;Department of Gastroenterology,Yangdong District People’s Hospital,Yangjiang 529500,China)

机构地区：[1]中国人民解放军南部战区总医院,广州510510 [2]南方医科大学中医药学院,广州510515 [3]阳东区人民医院消化内科,广东阳江529500

出　　处：《中国临床解剖学杂志》2020年第5期574-577,共4页Chinese Journal of Clinical Anatomy

基　　金：中国博士后科学基金项目资助(2019TQ0140,2019M663013)。

摘　　要：目的从肠道菌群和免疫炎症调控的角度,探讨润燥止痒胶囊(Runzao Zhiyang capsule,RZC)对银屑病样皮损的药效作用。方法研究RZC给药对银屑病样皮损模型大鼠的作用,检测血清中细胞炎症因子(IL-6和TNF-α、IL-17和IL-10)水平,分析模型大鼠粪便重要菌落的数量。结果给药RZC两周后,显著改善模型大鼠的银屑病样皮损症状。RZC下调血清IL-6、TNF-α和IL-17含量,上调IL-10水平,提示对机体炎症反应的缓解作用。给药降低模型大鼠肠道的肠杆菌和肠球菌的含量,提高乳酸杆菌和双歧杆菌的数目。结论 RZC治疗银屑病样皮损可能与其调控肠道菌群结构,缓解宿主免疫炎症反应有关。Objective To explore the effects of Runzao Zhiyang capsule(RZC) on psoriatic lesions from the perspective of regulation on gut microbiota and immune inflammation. Methods Effect of RZC on rat model with psoriatic lesions was studied. Levels of inflammatory cytokines(IL-6、TNF-α、IL-17 and IL-10) in the plasma were detected. The number of major bacterial colonies in feces was analyzed. Results After treatment with RZC for two weeks, symptoms of psoriatic lesions in rats were significantly improved.The levels of IL-17, IL-6, and TNF-α in the plasma were down-regulated by RZC, but the IL-10 level was upregulated by RZC, respectively, which indicating the amelioration of inflammatory response. RZC also reduced the amounts of escherichia and enterococcus, and increased the number of lactobacillus and bifidobacteria in the gut. Conclusions RZC treats psoriatic lesions, which maybe related to modulating gut microbial structure, and ameliorating immune inflammatory response of the host.

关 键 词：润燥止痒胶囊 银屑病样皮损 肠道菌群 炎症反应 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]