miRNA介导创伤性颅脑损伤继发性损伤病理机制的研究进展  

Micro RNA is involved in progression of secondary pathological process of traumatic brain injury

作　　者：翟科峰 段红 汪佳婕 吴嘉 汪俊军 Zhai Kefeng;Duan Hong;Wang Jiajie;Wu Jia;Wang Junjun(College of Biological and Food Engineering,Suzhou University,Suzhou 234000,China;Department of Clinical Laboratory,General Hospital of Eastern Theater Command of People's Liberation Army,Nanjing 210002,China)

机构地区：[1]宿州学院生物与食品工程学院,宿州234000 [2]解放军东部战区总医院临床检验科,南京210002

出　　处：《中华神经医学杂志》2020年第10期1052-1056,共5页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(81601034);安徽省杰出青年基金(2008085J39);安徽省重点研究与开发计划项目(1804a0802225);安徽省教育厅自然科学研究重大项目(KJ2018ZD044)。

摘　　要：创伤性颅脑损伤(TBI)是由外部创伤致使脑组织损伤、脑功能障碍的一类疾病,目前其病理机制尚未完全阐明,临床上也暂无优良的治疗方案。TBI可根据发生时间初步分为原发性损伤和继发性损伤。近年来大量研究者开始寻找微小RNA(miRNA)等有效生物信号分子,以期尽早发现并干预TBI后强烈的继发性损伤。研究表明miRNA作为小型非编码RNA在中枢神经系统疾病的病理进程中起关键作用,被认为是病理生理条件下神经功能的有效调节因子。本文通过综述miRNA影响神经细胞凋亡、炎性因子表达、血脑屏障修复三大途径中不同的干预作用,探讨miRNA对TBI的发生发展与恢复作用,以期促进miRNA在TBI方面的研究。Traumatic brain injury(TBI)is a kind of disease in which brain tissue injury and brain dysfunction are caused by external trauma.At present,the pathological mechanism of TBI is not fully clear,and there is no good clinical treatment plan.TBI can be preliminarily divided into primary injury and secondary injury according to the occurrence time.In recent years,a large number of researchers have begun to look for effective biological signaling molecules such as micro RNA(miRNA)to discover and intervene in secondary injury with strong response after TBI as early as possible.MiRNA,as a small non-coding RNA,can play a key role in the pathological process of central nervous system diseases,which is considered as an effective regulator of nerve function under pathophysiological conditions.In this paper,the effects of miRNA on the occurrence,development and recovery of TBI are summarized through the three major mechanisms of nerve cell apoptosis,inflammatory cytokine expression and blood-brain barrier repair,which lays the foundation for researching function of miRNA in TBI.

关 键 词：创伤性颅脑损伤 微小RNA 细胞凋亡 炎症反应 血脑屏障 

分 类 号：R651.15[医药卫生—外科学]