类风湿性关节炎患者维生素D和免疫球蛋白水平及相关性分析  

Analysis of vitamin D and immunoglobulin levels and the correlation in patients with rheumatoid arthritis

作　　者：程连娜 黄振强 郑海雅[1] CHENG Lian-na;HUANG Zhen-qiang;ZHENG Hai-ya(Clinical Laboratory,Lishui People’s Hospital,Lishui,Zhejiang 32300Q,China)

机构地区：[1]丽水市人民医院检验科,浙江丽水323000

出　　处：《中国卫生检验杂志》2020年第18期2224-2226,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的探讨类风湿性关节炎患者血清中维生素D和免疫球蛋白水平变化。方法选取本院2017年3月-2019年3月的80例RA患者作为观察组,同期健康体检者64例作为对照组,检测2组血清中25羟基维生素D[25(OH)D]水平,同时检测2组血清免疫球蛋白Ig G、Ig A、Ig M,补体C3、C4水平,并分析维生素D和免疫检测指标的相关性。结果类风湿性关节炎患者体内25羟基维生素D3水平显著低于健康体检者,差异有统计学意义(P<0.05),Ig G、Ig A、Ig M水平显著高于健康体检者,差异有统计学意义(P<0.05),C3、C4与对照组相比没有统计学差异,维生素D与红细胞沉降率(ESR)、抗环瓜氨酸肽(CCP)抗体呈显著负相关,与类风湿因子(RF)、免疫球蛋白等无明显相关性。结论类风湿性关节炎患者维生素D和免疫球蛋白水平与正常人相比存在显著差异,可帮助提高疾病的诊断准确性。Objective To investigate the changes of serum vitamin D and immunoglobulin levels in patients with rheumatoid arthritis.Methods A total of 80 patients with RA in our hospital from March 2017 to March 2019 were selected as observation group and 64 healthy people in the same period as control group.The levels of 25-hydroxyvitamin D[25(OH)D]were detected in the two groups,and meanwhile,the levels of Ig G,Ig A,Ig M,C3 and C4 were also detected to analyze the correlation between vitamin D and immune detection indicators.Results The level of 25-hydroxyvitamin D3 in patients with RA was significantly lower than that in healthy subjects,and the difference was statistically significant(P<0.05).The levels of Ig G,Ig A and Ig M were significantly higher than those in healthy subjects,and the difference was statistically significant(P<0.05).There was no statistical significance on the difference of C3 and C4 compared with the control group;vitamin D was significantly negatively correlated with ESR and CCP and had no significant correlation with RF and immunoglobulin.Conclusion The levels of vitamin D and immunoglobulin in patients with RA are significantly different compared with the control group,which can help us to improve the diagnostic accuracy of the disease.

关 键 词：类风湿性关节炎 维生素D 免疫球蛋白 

分 类 号：R593.22[医药卫生—内科学]