道路交通事故所致颅脑损伤患者血浆铜蓝蛋白水平的动态变化  

Dynamic variation of serum ceruloplasmin in patients with traumatic brain injury due to traffic accident

作　　者：林勇[1] 沈建根[1] 濮正平 郭子雷[1] 蔡继明 沈震 LIN Yong;SHEN Jian-gen;PU Zheng-ping;GUO Zi-lei;CAI Ji-m ing;SHEN Zhen(Department of Psychiatry,Kangci Hospital of Jiaxing,Jiaxing,Zhejiang 314500,China;不详)

机构地区：[1]浙江省嘉兴市康慈医院精神科,浙江嘉兴314500 [2]浙江省嘉兴市第二医院ICU,浙江嘉兴314000 [3]浙江省桐乡市第一人民医院神经科,浙江桐乡314500

出　　处：《中国卫生检验杂志》2020年第18期2271-2273,2276,共4页Chinese Journal of Health Laboratory Technology

基　　金：嘉兴市科技计划项目(2017BY18104);桐乡市重点科技计划项目(201701011)。

摘　　要：目的探讨道路交通事故所致颅脑损伤患者不同时段血浆铜蓝蛋白的动态变化及特点。方法采用回顾性病例对照研究分析2017年1月-2018年3月入组的68例急性期与298例慢性期道路交通事故所致颅脑损伤患者,另纳入对照组40例,分别于外伤后12 h内、半年后2个时段检测患者血浆铜蓝蛋白水平,对照组检测空腹血浆铜蓝蛋白水平;急性期患者使用格拉斯哥昏迷评定量表(GCS)评估创伤严重程度,慢性期患者使用韦氏智力测验(WAIS)评估智能水平,结合智力损害的程度分为边缘、轻度、中毒、重度智能损害。结果急性期患者血浆铜蓝蛋白较健康对照组、慢性期患者升高,差异有统计学意义(F=6.391,P=0.001);慢性期(边缘、轻度、中度、重度)智能损害患者之间血浆铜蓝蛋白比较差异无统计学意义(P>0.05)。急性期患者GCS评分与血清铜蓝蛋白浓度之间呈负相关(r=-0.089,P<0.05)。结论道路交通事故所致颅脑损伤急性期血浆铜蓝蛋白升高,与颅脑损伤严重程度存在关联,早期血浆铜蓝蛋白变化对道路交通事故所致颅脑损伤严重程度具有预测价值。Objective To explore the dynamic variation of serum ceruloplasmin(CER)in patients with traumatic brain injury(TBI)due to traffic accident.Methods We performed a retrospective,case-control study to evaluate the outcomes.68 acute and 298 chronic patients with TBI from Jan 2017 to Mar 2018 were selected as experimental subjects,and 40 healthy persons were enrolled as control cases.The serum levels of CER were determined within 12 hours after traffic accident in acute TBI patients,half a year later after traffic accident in chronic TBI patients,and at fasting state in healthy control group.Glasgow Coma Scale(GCS)was used to assess the severity of injury in acute TBI patients.Wechsler Adult Intelligence Scale(WAIS)was used to assess intelligence of chronic TBI patients,by which the chronic TBI patients were divided into the edge intelligence group and mild,moderate,and severe intellectual disability groups.Results The serum CER level in acute TBI patients was higher than chronic TBI patients and healthy persons,with the differences statistical significance(F=6.391,P=0.001).There’s no statistical significance on the difference in serum CER level among the edge intelligence group and mild,moderate,and severe intellectual disability groups(P>0.05).There’s a negative correlation between the GCS scores and serum CER levels(r=-0.089,P<0.05).Conclusion The serum CER level rises in acute TBI patients,which has a relationship to the severity of brain injury.There’s a predictable value in early variation of serum CER level for TBI patients due to traffic accident.

关 键 词：脑外伤 铜蓝蛋白 道路交通事故 认知功能 

分 类 号：R651.15[医药卫生—外科学]