Radical Heteroarylalkylation of Alkenes via Three-Component Docking-Migration Thioetherification Cascade  

作　　者：Tao Niu Jige Liu Xinxin Wu Chen Zhu 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,199 Ren-Ai Road,Suzhou,Jiangsu 215123,China [2]Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Road,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2020年第8期803-806,共4页中国化学（英文版）

基　　金：C.Z.is grateful for the financial support from the NationalNatural Science Foundation of China(Nos.21722205,21971173);the Project of Scientific and Technologic Infrastructure of Suzhou(SzS201905);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).

摘　　要：A novel,rational-designed approach to access various heteroaryl-substituted alkyl thioethers was developed via docking-migration cascade process.By utilizing three components involving alkene,dual-function reagent,and thioetherificating reagent,radical heteroarylalkylation of alkenes followed by thiolation of the alkyl radical intermediates proceeded smoothly,manifesting well compatibility of substrates and cascade transformations.Furthermore,this protocol also features mild conditions,broad substrate scope,and wide product diversity.

关 键 词：process REAGENT ALKYLATION 

分 类 号：O62[理学—有机化学]