Sequential Ir-Catalyzed Allylation/2-aza-Cope Rearrangement Strategy for the Construction of Chiral Homoallylic Amines  

作　　者：Ruo-Qing Wang Chong Shen Xiang Cheng Zuo-Fei Wang Hai-Yan Tao Xiu-Qin Dong Chun-Jiang Wang 

机构地区：[1]Engineering Research Center of Organosilicon Compounds&Materials,Ministry of Education,College of Chemistry and Molecular Sciences,Wuhan University,Wuhan,Hubei 430072,China [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 230021,China

出　　处：《Chinese Journal of Chemistry》2020年第8期807-811,共5页中国化学（英文版）

基　　金：We are grateful for financial support from the National Natural Science Foundation of China(Grant Nos.21525207,21772147to C.J.W.);Natural Science Foundation of Jiangsu Province(Grant No.SKB2019041078 to X.Q.D.);Wuhan Morning Light Plan ofYouth Science and Technology(Grant No.2017050304010307 to X.Q.D.);Postdoctoral Innovative Talent Support Program of china(BX20190253 to C.s.).We thank Prof.Shu-Li You at SloC forgenerously providing(R,R)-THQ-Phos;The Program of Introducing Talents of Discipline to Universities of China(111 Project)is alsoappreciated.

摘　　要：Sequential Ir-catalyzed asymmetric allylation/2-aza-Cope rearrangement of arylidene aminomalonates with allylic carbonates was successfully developed,and a variety of enantioenriched homoallylic amine derivatives were obtained in high yields with good chirality transfer and excellent E/Z-geometry control(up to 99%yield,96%ee).Compared with previous dual catalytic system established for this transformation,the current mono metal catalytic system provides a simpler and more practical protocol employing the readily available starting materials.

关 键 词：materials system STARTING 

分 类 号：O62[理学—有机化学]