3-对氯苯基-3-(N-对硝基苯基氨基)苯丙酮的合成及结构研究  

Synthesis and Structural Research of 3-(4-Chlorophenyl)-3-((4-Nitrophenyl)amino)-1-Phenylpropanone

作　　者：孙佳慧 申茗月 刘春玲[1] Sun Jiahui;Shen Mingyue;Liu Chunling(College of Chemistry,Jilin Normal University,Siping 136000,China)

机构地区：[1]吉林师范大学化学学院,吉林四平136000

出　　处：《山东化工》2020年第18期32-34,43,共4页Shandong Chemical Industry

摘　　要：在冰水浴冷却及少量浓盐酸催化下,对氯苯甲醛、对硝基苯胺和苯乙酮发生Mannich反应,经过提纯得到β-氨基酮。该化合物属于单斜晶系,P 2(1)/n空间群,晶胞参数a=9.205(2),b=12.140(3),c=17.034(4),α=90°,β=98.451(4)°,γ=90°,V=1882.9(7)3,Z=4,D c=1.343 g/cm^3,R 1=0.0445,wR 2=0.1150。化合物通过分子间C-H···O氢键形成了一维链状结构。Under the ice-water bath and a small amount of concentrated hydrochloric acid as catalyst,p-chlorobenzaldehyde,p-nitroaniline and acetophenone can react to yieldβ-aminoketone.The compound belongs to monoclinic system,P 2(1)/n space group,lattice parameters a=9.205(2),b=12.140(3),c=17.034(4),α=90°,β=98.451(4)°,γ=90°,V=1882.9(7)3,Z=4,D c=1.343 g/cm 3,R 1=0.0445,wR 2=0.1150.The compound formed the one-dimensional chain structure by intermolecular C-H···O hydrogen bond.

关 键 词：MANNICH反应 β-氨基酮 对氯苯甲醛 苯乙酮 对硝基苯胺 

分 类 号：O621.3[理学—有机化学]