呋喃并[3,2-b]吡啶衍生物的高效合成  

Efficient Synthesis of Furo[3,2-b]pyridine Derivatives

作　　者：范威 FAN Wei(Department of Medicine,Chuzhou Cty Vocation College,Anhui Chuzhou 239000,China)

机构地区：[1]滁州城市职业学院医学系,安徽滁州239000

出　　处：《河北师范大学学报（自然科学版）》2020年第6期516-520,共5页Journal of Hebei Normal University：Natural Science

基　　金：滁州城市职业学院重点项目(2019jyxm02);滁州城市职业学院院级科研项目(2020ZK03,2020ZK05)。

摘　　要：以取代的查尔酮环氧化物和呋喃酮为原料,乙二醇为溶剂,在碳酸铯促进下通过去质子、亲核取代、氢转移、分子内Knoevenagel缩合等过程,合成了呋喃并[3,2-b]吡啶衍生物,单晶衍射分析证实了产物结构.该反应为大量合成呋喃并[3,2-b]吡啶化合物提供了有效的方法.Using substituted chalcone epoxide and furanone as raw materials,ethylene glycol as solvent,under the promotion of cesium carbonate,furo[3,2-b]pyridines were synthesized through deprotonation,nucleophilic substitution,hydrogen transfer,and intramolecular Knoevenagel condensation,etc.The structures of products were confirmed by the single crystal X-ray diffraction.This reaction provided an effective method for the synthesis of furo[3,2-b]pyridines in large quantities.

关 键 词：呋喃酮 呋喃并[3 2-b]吡啶衍生物 一步反应 

分 类 号：O626[理学—有机化学]