新型多功能可生物降解PEG-PLA/PLGA/PCL聚合物纳米抗肿瘤药物载体的研究进展  

Research Progress of Novel Multi-functional Biodegradable PEG-PLA/PLGA/PCL Polymeric Nano-anticancer Drug Carriers

作　　者：赵广阔 苏为科[1] 帅棋 ZHAO Guangkuo;SU Weike;SHUAI Qi(Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]浙江工业大学长三角绿色制药协同创新中心,杭州310014

出　　处：《中国现代应用药学》2020年第18期2291-2298,共8页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目(21606202)。

摘　　要：PEG-PLA/PLGA/PCL聚合物药物载体因具备可生物降解性、高包封率、靶向运输、可控释放及可修饰的特性,在癌症治疗的应用中得到越来越广泛的关注。然而,PEG-PLA/PLGA/PCL聚合物材料作为抗癌药物的递送载体仍然面临诸多的挑战:聚合物药物载体结构的不稳定性;靶向运输的效果不明显;药物在肿瘤组织释放不完全等。因此,设计出新型的PEG-聚酯类聚合物药物载体成为研究的前沿和热点。本文综述了近年来国内外研究学者在构建多功能性的PEG-聚酯类聚合物纳米抗肿瘤药物载体的研究成果,从提高结构稳定、增强靶向能力以及刺激响应释放3种设计理念对不同的纳米载药体系进行讨论、分析和总结。The application of PEG-PLA/PLGA/PCL polymer as novel drug delivery system for cancer treatment has been extensively investigated due to its biodegradability,high encapsulation efficiency,targeted transportation and controllable release profile of drug,tunability of structure and properties.However,there are still many challenges in the development of PEG-PLA/PLGA/PCL polymeric anticancer drug carriers:structural instability of polymeric drug carriers;poor effect of targeted transportation;insufficient drug release in tumor tissue,etc.Therefore,the design of novel PEG-polyester polymeric drug carriers has been a hot area of research.This paper review the study of new designs of multi-functional biodegradable PEG-PLA/PLGA/PCL polymeric nano-anticancer drug carriers in recent years,and a series of different nano-carrier systems were discussed,analysed and summed in three design concepts:improving structural stability,enhancing targeting ability and stimulating drug release.

关 键 词：聚合物载体 抗肿瘤药物 纳米载药体系 

分 类 号：R943[医药卫生—药剂学]