肺移植术后早期急性肾损伤的研究进展  

Research progress on early acute kidney injury after lung transplantation

作　　者：陈奥 练巧燕 徐鑫[1] 韦兵[1] 刘梦杨 彭桂林[1] 张建恒[1] 何建行[1] 巨春蓉[1] Chen Ao;Lian Qiaoyan;Xu Xin;Wei Bing;Liu Mengyang;Peng Guilin;Zhang Jianheng;He Jianxing;Ju Chunrong(Department of Transplantation,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Health,Guangzhou 510012,China)

机构地区：[1]广州医科大学附属第一医院移植科广州呼吸健康研究院,510012

出　　处：《器官移植》2020年第6期743-748,共6页Organ Transplantation

基　　金：广东省自然科学基金(2018A030313107)。

摘　　要：急性肾损伤(AKI)是肺移植术后早期常见并发症之一,AKI不仅导致肺移植受者术后近期及远期病死率增加,且显著增加术后远期慢性肾功能不全的发生率。近年来,随着肺移植在中国的迅速发展,肺移植术后早期AKI也引起高度关注。本文对近年来国际上关于肺移植术后早期AKI的诊断、发生情况、危险因素、防治等方面的研究进展进行综述,旨在更好地识别肺移植术后早期AKI相关的危险因素及其不良预后,为临床早期干预提供理论及实践指导。Acute kidney injury(AKI)is one of the common early complications after lung transplantation,which not only increases the short-term and long-term fatality of lung transplant recipients,but also significantly increases the incidence of long-term chronic renal insufficiency after surgery.In recent years,early AKI after lung transplantation has attracted high attention along with the rapid development of lung transplantation in China.In this article,research progresses on diagnosis,incidence,risk factors,prevention and treatment of early AKI after lung transplantation around the globe were reviewed,aiming to better identify the risk factors and poor prognosis of early AKI after lung transplantation,and provide theoretical and practical guidance for early clinical interventions.

关 键 词：肺移植 急性肾损伤 持续性肾脏替代治疗 体外膜肺氧合 机械通气 血清肌酐 肾小球滤过率 中性粒细胞明胶酶相关脂质运载蛋白 

分 类 号：R617[医药卫生—外科学] R563[医药卫生—临床医学]