金葡菌感染引发的天然免疫防御效应研究进展  

Research progress in innate defense against infection of Staphylococcus aureus

作　　者：石婷 李甜甜 郑月娟(指导)[1] SHI Ting;LI Tian-Tian;ZHENG Yue-Juan(School of Basic Medical Sciences,Shanghai University of Traditional Chinese Medicine,Shanghai Key Laboratory of Health Identification and Assessment,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学基础医学院,上海中医药大学上海市健康辨识与评估重点实验室,上海201203

出　　处：《中国免疫学杂志》2020年第19期2419-2424,2428,共7页Chinese Journal of Immunology

基　　金：国家重点研发计划应急项目(2020YFC0845400);上海高校特聘教授(东方学者)计划;上海市中医药防治新冠肺炎科研攻关项目(2020XGKY10)资助。

摘　　要：金黄色葡萄球菌是引起院内和社区感染的重要病原菌之一,可引发局部组织化脓性感染,甚至导致脓毒症等全身性感染,危害人类健康。多重耐药菌-耐甲氧西林金黄色葡萄球菌(MRSA)感染已成为全球性治疗难题。宿主导向治疗(HDT)通过调控宿主免疫反应控制病原菌感染并保护机体,可有效辅助抗生素治疗细菌感染,是感染性疾病尤其是耐药菌感染治疗的新思路。天然免疫应答是抵抗外来病原菌入侵的第一道防线,当机体感染金葡菌后,迅速募集和激活宿主天然免疫细胞,产生天然免疫应答,并激活适应性免疫应答,最终清除病原菌。本文主要综述近年天然免疫反应在宿主防御金葡菌感染方面的研究进展。As one of main pathogens of nosocomial and community-acquired infections,staphylococcus aureus can cause pyogenic infection of local tissue,even systemic infection such as sepsis,which leads to serious threat to public health worldwide.Infection caused by methicillin-resistant Staphylococcus aureus(MRSA) has become a global challenge.Host-directed therapy(HDT) aims to control bacterial infection and offer protection by regulating immune response whereas bypassing problem of antibiotic resistance,which is an emerging and adjuvant strategy for treatment of infectious diseases,especially those caused by drug-resistant pathogens through regulating host immune response.Innate immune response constitutes first line of defense against invasive pathogens.Innate immune cells are rapidly recruited and activated to induce immune response when infected by S.aureus.This review mainly presents a comprehensive overview of innate immune response against S.aureus infection in recent years.

关 键 词：金黄色葡萄球菌 耐甲氧西林金黄色葡萄球菌 天然免疫细胞 宿主导向治疗 

分 类 号：R392.1[医药卫生—免疫学]