高频超声结合超声弹性成像在定量评估糖尿病患者前臂外周神经病变中的应用价值  

Application value of high-frequency ultrasound combined with ultrasonic elastography in quantitative evaluation of diabetic peripheral neuropathy of the forearm in diabetic patients

作　　者：王佳佳[1] 周秋梅 刘晨旭 李家云[4] 肖蕾[1] 张靖[1] Wang Jiajia;Zhou Qiumei;Liu Chenxu;Li Jiayun;Xiao Lei;Zhang Jing(Department of Ultrasound Medicine,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230000,Anhui,China;Experimental Center of The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230000,Anhui,China;Grade 2018 of Basic Medicine School,Bengbu Medical College,Benbu 233000,Anhui,China;Department of Endocrinology,The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei 230000,Anhui,China)

机构地区：[1]安徽中医药大学第一附属医院超声医学科,安徽合肥230000 [2]安徽中医药大学第一附属医院实验中心,安徽合肥230000 [3]蚌埠医学院基础医学院,安徽蚌埠233000 [4]安徽中医药大学第一附属医院内分泌科,安徽合肥230000

出　　处：《右江民族医学院学报》2020年第5期574-577,共4页Journal of Youjiang Medical University for Nationalities

基　　金：安徽省自然科学基金项目(1808085QH250);安徽高校自然科学研究项目(KJ2018A0290)。

摘　　要：目的探讨高频超声结合超声弹性成像在评估糖尿病患者前臂外周神经病变(DPN)中的可行性。方法分别测量正常对照组(A组)、神经损伤早期组(B组)、神经损伤中后期组(C组)各30例研究对象正中神经(MN)、尺神经(UN)的周长、横截面积、杨氏模量,比较上述参数在三组研究对象中差异有无统计学意义,同时分析上述参数与感觉神经定量检测的电流阈值(CPT)评分的相关性。结果研究对象MN、UN的周长、横截面积、杨氏模量与感觉神经定量检测的电流阈值评分均呈正相关(rMN=0.943、0.957、0.985;rUN=0.933、0.859、0.925),且A组、B组、C组三组间MN、UN的周长、横截面积、杨氏模量两两比较差异均有统计学意义(P<0.001)。结论高频超声为临床诊断DPN以及评估DPN病变程度分级提供更加全面的量化指标。Objective To explore the feasibility of high-frequency ultrasound combined with ultrasonic elastography in the evaluation of diabetic peripheral neuropathy(DPN).Methods The perimeter,cross-sectional area and Young’s modulus of median nerve(MN)and ulnar nerve(UN)were measured respectively in the normal control group(group A),the early nerve injury group(group B)and the middle and late nerve injury group(group C),with 30 cases in each group.The differences of the above parameters among the three groups were compared,and correlation between the above parameters and the current perception thresholds(CPT)scores on quantitative detection of sensory nerve was analyzed.Results The perimeter,cross-sectional area and Young’s modulus of MN and UN in the research objects were positively correlated with the CPT score(rMN=0.943,0.957,0.985;rUN=0.933,0.859,0.925).Moreover,the pairwise comparison of perimeter,cross-sectional area and Young’s modulus of MN and UN among group A,group B and group C showed significant difference(P<0.001).Conclusion High-frequency ultrasound provides more comprehensive quantitative indicators for the clinical diagnosis of DPN and assessment of the degree of DPN lesions.

关 键 词：糖尿病外周神经病变 剪切波速度成像技术 

分 类 号：R587.2[医药卫生—内分泌]