宣肺化痰平喘法治疗急性期喘息性支气管炎患儿的临床疗效及对动脉血气指标、嗜酸性粒细胞趋化因子、白细胞介素6、白细胞介素8、肿瘤坏死因子α水平的影响  

Clinical efficacy of Xuanfei Huatan Pingchuan method in the treatment of acute asthmatic bronchitis and its influence on arterial blood gas index,eosinophil chemoattractant factor,interleukin-6,interleukin-8 and tumor necrosis factorαlevels

作　　者：邓小梅 周渊 冉启锋 DENG Xiaomei;ZHOU Yuan;RAN Qifeng(Department of Traditional Chinese Medicine,The First Maternal and Child Health Center,Huizhou,Guangdong 516000)

机构地区：[1]广东省惠州市第一妇幼保健院中医科,广东惠州516000

出　　处：《河北中医》2020年第7期986-989,994,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：2018年度广东省医学科学技术重点研究基金项目(编号:2018-YS001538)。

摘　　要：目的观察宣肺化痰平喘法治疗急性期喘息性支气管炎的临床疗效,以及对动脉血气指标、嗜酸性粒细胞趋化因子(Eotaxin)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)及IL-8水平的影响。方法将96例急性期喘息性支气管炎患儿按照随机数表法分为2组。对照组48例予西医常规治疗,治疗组48例在对照组基础上加用宣肺化痰平喘中药治疗。2组均治疗10 d后统计疗效,比较2组治疗后肺部哮鸣音、咳嗽及喘憋症状开始缓解时间,比较2组治疗前后动脉血气指标氧分压[p(O 2)]及二氧化碳分压[p(CO 2)]水平变化情况,比较2组治疗前后Eotaxin、TNF-α、IL-6及IL-8水平变化情况。结果治疗组总有效率95.83%(46/48),对照组总有效率66.67%(32/48),治疗组疗效优于对照组(P<0.05),且治疗组肺部哮鸣音、咳嗽及喘憋症状缓解所需时间均短于对照组(P<0.05)。与本组治疗前比较,2组治疗后p(O 2)水平均升高(P<0.05),p(CO 2)水平均下降(P<0.05),且治疗组治疗后p(O 2)及p(CO 2)水平改善均优于对照组(P<0.05)。2组治疗后Eotaxin、TNF-α、IL-6及IL-8水平与本组治疗前比较均下降(P<0.05),且治疗组治疗后各项指标水平均低于对照组(P<0.05)。结论宣肺化痰平喘法治疗急性期喘息性支气管炎患儿临床疗效确切,可明显缩短症状改善时间,改善患儿的动脉血气指标,降低Eotaxin、TNF-α、IL-6及IL-8水平,抑制炎性反应,提高临床疗效。Objective To observe the effect of Xuanfei Huatan Pingchuan method in the treatment of acute asthmatic bronchitis and its influence on arterial blood gas index,eosinophil chemoattractant(Eotaxin)factor,tumor necrosis factorα(TNF-α),interleukin(IL)-6 and IL-8 levels.Methods 96 children with acute asthmatic bronchitis were randomly divided into two groups according to the random number table method.48 cases in the control group were given routine western medicine treatment.48 cases in the treatment group were treated by Xuanfei Huatan Pingchuan Chinese medicine on the basis of the control group.After 10 days of treatment,the curative effect was counted.Compare the time when the symptoms of lung wheezing,cough and wheezing begin to relieve after treatment in the two groups.The changes of arterial partial pressure of oxygen[p(O 2)]and partial pressure of carbon dioxide[p(CO 2)]before and after treatment were compared between the two groups,and the changes of levels of eotaxin,TNF-α,IL-6 and IL-8 were compared between the two groups before and after treatment.Results The total effective rate of the treatment group was 95.83%(46/48)and that of the control group was 66.67%(32/48).The curative effect of the treatment group was better than that of the control group(P<0.05).After treatment,the time required for relieving wheezing,cough and wheezing symptoms in the treatment group was shorter than that in the control group(P<0.05).Compared with before treatment,the levels of p(O 2)was increased(P<0.05)and p(CO 2)was decreased in both groups after treatment(P<0.05),and the improvement of p(O 2)and p(CO 2)in the treatment group was better than that in the control group.After treatment,the levels of Eotaxin,TNF-α,IL-6 and IL-8 in both groups were decreased compared with those in the group before treatment(P<0.05),and the levels of all indexes in the treatment group were lower than those in the control group(P<0.05).Conclusion Xuanfei Huatan Pingchuan method has a definite clinical effect in the treatment of acute asthmatic

关 键 词：支气管炎 喘证 中药疗法 宣肺平喘 祛痰平喘 

分 类 号：R289.61[医药卫生—方剂学] R725.622.1[医药卫生—中药学]