ACE2/Ang(1-7)/Mas轴在心血管疾病中的研究进展  

Research Progress of ACE2/Ang(1-7)/Mas Axis in Cardiovascular Disease

作　　者：黎秀芝 尹新华[1] LI Xiuzhi;YIN Xinhua(Department of Cardiology,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院心内科,哈尔滨150001

出　　处：《医学综述》2020年第20期3969-3975,共7页Medical Recapitulate

基　　金：国家自然科学基金(81570437)。

摘　　要：血管紧张素转换酶(ACE)2/血管紧张素(Ang)(1-7)/Mas轴为肾素-血管紧张素系统(RAS)的主要成员之一,是经典RAS成员ACE/AngⅡ/Ang1型受体轴的反调控轴。其中,ACE2主要通过水解AngⅠ或AngⅡ而产生Ang(1-7),Ang(1-7)通过与其特异性受体Mas结合,发挥舒张血管、抗炎、抗氧化应激、抗血栓形成、抗纤维化、抗血管和心室重构等生物学作用。ACE2/Ang(1-7)/Mas轴在心血管系统中高表达,未来应对其在心血管系统疾病中的作用进行深入研究,以期为心血管疾病的防治寻找新的、更有效的潜在靶点提供新思路。The angiotensin converting enzyme(ACE)2/angiotensin(Ang)(1-7)/Mas axis is one of the main members of the renin-angiotensin system(RAS),and is the reverse regulation axis of ACE/AngⅡ/Ang 1 receptor axis,the classic RAS member.Among them,ACE2 mainly produces Ang(1-7)by hydrolyzing AngⅠor AngⅡ,and Ang(1-7)plays the biological roles of vasodilation,anti-inflammation,anti-oxidative stress,anti-thrombosis,anti-fibrosis,anti-vascular and ventricular remodeling by binding to its specific Mas receptor.ACE2/Ang(1-7)/Mas axis is highly expressed in the cardiovascular system.In the future,we should further explore its role in cardiovascular diseases in order to find new and more effective potential targets for the prevention and treatment of cardiovascular diseases.

关 键 词：心血管疾病 血管紧张素转换酶2 血管紧张素(1-7) MAS受体 

分 类 号：R714.252[医药卫生—妇产科学]