microRNA在原发性高血压病理机制中的研究进展  

Advances in Study of MicroRNAs in Pathogenesis of Essential Hypertension

作　　者：朱丹 胡大春 ZHU Dan;HU Dachun(Department of Clinical Laboratory,Affiliated Calmette Hospital of Kunming Medical University/the First Hospital of Kunming,Kunming 650011,China)

机构地区：[1]昆明医科大学附属甘美医院昆明市第一人民医院检验科,昆明650011

出　　处：《医学综述》2020年第20期3992-3998,共7页Medical Recapitulate

基　　金：云南省科技计划项目(2017FE468(-098));昆明市科技计划项目(2016-1-S-06350)。

摘　　要：原发性高血压(EH)发病机制复杂,遗传因素和环境因素相互作用导致机体血压调节机制失衡,血压病理性升高。血压的形成涉及心脏、血容量和血管的相互作用与协调,肾脏、神经、体液等因素参与维持血压的稳态,其中任何一方面失控均可导致血压变化。遗传因素、交感神经系统兴奋过度、钠过多、肾素-血管紧张素-醛固酮系统异常等是血压持续升高的重要病理机制。非编码RNA中微RNA(miRNA)广泛参与上述病理过程,在高血压人群的各种组织、体液及高血压遗传动物模型中均发现miRNA失调,miRNA可能成为EH的生物标志物及治疗靶点。The pathogenesis of essential hypertension(EH)is complicated.The interaction between genetic factors and environmental factors leads to the imbalance of blood pressure regulation mechanism and the pathological increase of blood pressure.The formation of blood pressure involves the interaction and coordination of the heart,blood volume and blood vessels.Various regulatory factors such as kidney,nerve and body fluid are involved in maintaining blood pressure homeostasis,and any one of them out of control can lead to changes in blood pressure.The genetic factors,hyperexcitability of the sympathetic nervous system,excessive sodium,abnormal renin-angiotensin-aldosterone system are the important pathological mechanisms for the continuous increase of blood pressure.MicroRNAs(miRNAs)in non-coding RNAs are widely involved in the above pathological process.and many dysregulated miRNAs also have been found in various human tissues,body fluids and genetic animal models of hypertension,suggesting that miRNA may become a biomarker and therapeutic target for EH.

关 键 词：原发性高血压 微RNA 病理机制 血管平滑肌细胞 肾素-血管紧张素-醛固酮系统 内皮细胞 

分 类 号：R544.1[医药卫生—心血管疾病]