截叶铁扫帚提取物促胃肠动力作用初探  

PRELIMINARY STUDY ON GASTROINTESTINAL MOTILITY OF LESPEDEZA CUNEATA EXTRACT

作　　者：钟卫华 梁生林 ZHONG Wei-hua;LIANG Sheng-lin(Affiliated Hospital of Jinggangshan University,Ji´an Jiangxi 343000,China;Health Science Center,Jinggangshan University,Ji´an Jiangxi 343009,China)

机构地区：[1]井冈山大学附属医院,江西吉安343000 [2]井冈山大学医学部,江西吉安343000

出　　处：《井冈山大学学报（自然科学版）》2020年第5期78-82,共5页Journal of Jinggangshan University (Natural Science)

基　　金：国家科技支撑计划课题子课题项目(2012BAC11B02-6);全国中药资源普查项目(财社[2018]43号)。

摘　　要：目的初步探究截叶铁扫帚水提物和醇提物对肠胃向下推进运动功能的影响。方法采用整体肠向下推进运动及胃排空实验法以及离体肠实验法,研究截叶铁扫帚水提物和醇提物对肠胃运动功能的影响。结果与蒸馏水组相比较,截叶铁扫帚水提物和醇提物高、低剂量(10.0、5.0 g生药/kg)组均使胃内容物残留率降低显著(P<0.01),小肠推进率明显提高(P<0.05,P<0.01);截叶铁扫帚水提物高剂量与相同剂量醇提物相比,在胃内容物残留率的降低和小肠推进率的提高两方面具有显著差异(P<0.05)。在离体实验中,与给药前比较,截叶铁扫帚水提物给药后的回肠管收缩幅度和收缩活动力显著强于给药前(P<0.01);截叶铁扫帚醇提物给药后回肠管收缩幅度也明显比给药前强(P<0.05);从家兔离体回肠收缩幅度、收缩活动力比较,截叶铁扫帚水提物显著比醇提物强(P<0.01)。结论截叶铁扫帚水提物和醇提物具有促进肠胃运动的作用,且水提物比醇提物强。Objective:To explore gastrointestinal motility of the water extract and alcohol extract from Lespedeza cuneata.Methods:The intestinal downward propulsion motor,gastric emptying experimental methods were used in investigating the influence of the stomach,bowel movement function of the water extract and alcohol extract from L.cuneata.Results:Compared with the distilled water group,high-and low-dose(10.0,5.0 g/kg)groups of the water and alcohol extract obviously decreased gastric content residual rates(P<0.01),and obviously increased the intestinal downward propulsion rates in mice(P<0.05,P<0.01).Compared with the same dose of alcohol extract,high-dose water extract obviously decreased the gastric content residual rates and increased the intestinal downward propulsion rates(P<0.05).In vitro experiments,after the administration of water extract,the contraction amplitude and activity of the isolated ileum increased significantly in rabbits(P<0.01);after the administration of alcohol extract,the contraction amplitude of the isolated ileum increased obviously in rabbits(P<0.05).The water extract had stronger effects than alcohol extract(P<0.01),based on the comparison of the contraction amplitude and activity of the isolated ileum in rabbits.Conclusion:The water extract and alcohol extract from L.cuneata had obvious effects on promoting gastrointestinal motility,and the water extract has stronger effects than the alcohol extract.

关 键 词：截叶铁扫帚 水提物和醇提物 胃肠运动 

分 类 号：R285.5[医药卫生—中药学]