地奥司明对睾丸鞘膜积液的疗效及其对CRP、HSP、PSA的影响研究  

Study on effect of diosmin on hydrocele and its effect on CRP,HSP,PSA

作　　者：刁玉荣 王睿 孙振层 赵晓智[2] DIAO Yurong;WANG Rui;SUN Zhenceng;ZHAO Xiaozhi(Department of Urology,Jiangbei District,Affiliated Zhongda Hospital,Southeast University,Nanjing,Jiangsu 210044,China;Department of Urology,Affiliated Hospital,Medical School of Nanjing University Nanjing,Jiangsu 213000,China)

机构地区：[1]东南大学附属中大医院江北院区泌尿外科,南京210044 [2]南京大学医学院附属医院泌尿外科,213000

出　　处：《重庆医学》2020年第20期3347-3349,3353,共4页Chongqing medicine

基　　金：国家自然科学基金青年基金项目(81302542)。

摘　　要：目的探讨地奥司明对睾丸鞘膜积液的疗效及其对C反应蛋白(CRP)、热休克蛋白(HSP)、前列腺特异抗原(PSA)表达的影响。方法选取2017年7月至2018年4月东南大学附属中大医院收治的62例睾丸鞘膜积液患者为研究对象,分为研究组和对照组,研究组使用地奥司明治疗,对照组使用消痔灵治疗。比较两组睾丸鞘膜积液疗效,CRP、HSP、PSA水平及慢性前列腺炎症状评分表(NIH-CPSI)评分变化。结果研究组疗效优于对照组(93.5%vs.64.5%,P<0.05)。治疗前两组CRP、HSP、PSA水平比较,差异无统计学意义(P>0.05);治疗后研究组CRP[(31.2±1.6)mg/L vs.(53.5±1.8)mg/L]、HSP[(3.2±0.3)ng/L vs.(8.8±0.4)ng/L]、PSA[(1.2±0.1)μg/L vs.(2.8±0.3)μg/L]水平明显低于对照组(P<0.05)。治疗前两组NIH-CPSI评分比较,差异无统计学意义(P>0.05);治疗后研究组NIH-CPSI评分低于对照组[(14.2±1.6)分vs.(26.5±1.8)分,P<0.05];研究组不良反应发生率明显低于对照组(6.5%vs.29.0%,P<0.05)。结论地奥司明能有效改善睾丸鞘膜积液,降低CRP、HSP、PSA水平。Objective To explore the effect of diosmin on hydrocele and its influence on C-reactive protein(CRP),heat shock protein(HSP)and prostate specific antigen(PSA).Methods A total of 62 patients with testicular hydrocele admitted to Affiliated Zhongda Hospital of Southeast University from July 2017 to April 2018 were selected as the study subjects and divided into the study group and the control group.The study group was treated with diosmin and the control group was used Xiaozhiling.The curative effect of hydrocele,levels of CRP,HSP and PSA,and the change of chronic prostatitis symptom scale(NIH-CPSI)scores were compared between the two groups.Results The efficacy of the study group was higher than that of the control group(93.5%vs.64.5%,P<0.05).There was no statistically significant difference in the levels of CRP,HSP,PSA before treatment between the two groups(P>0.05).After treatment,the levels of CRP[(31.2±1.6)mg/L vs.(53.5±1.8)mg/L],HSP[(3.2±0.3)ng/L vs.(8.8±0.4)ng/L]and PSA[(1.2±0.1)μg/L vs.(2.8±0.3)μg/L]in the study group were significantly lower than those in the control group(P<0.05).The comparison of NIH-CPSI scores before treatment between the two groups was not statistically significant(P>0.05);while the NIH-CPSI score after treatment in the study group was lower than that in the control group[(14.2±1.6)points vs.(26.5±1.8)points,P<0.05].The incidence rate of adverse reactions in the study group was significantly lower than that in the control group(6.5%vs.29.0%,P<0.05).Conclusion Diosmin could effectively improve hydrocele and reduce the levels of CRP,HSP and PSA.

关 键 词：地奥司明 睾丸鞘膜积液 C反应蛋白质 热休克蛋白质类 前列腺特异抗原 治疗结果 

分 类 号：R697+.22[医药卫生—泌尿科学]