新诊断青年2型糖尿病患者的相关影响因素分析  

Analysis of influencing factors in youth patients with newly diagnosed type-2 diabetes mellitus

作　　者：陈满 陈涌涌[1] 赵璐 胡华斌[1] 陈香均 汪志红[3] CHEN Man;CHEN Yongyong;ZHAO Lu;HU Huabin;CHEN Xiangjun;WANG Zhihong(Department of Endocrinology;Department of Cardiovasology,Chongqing Municipal Fifth People′s Hospital,Chongqing 400062,China;Department of Endocrinology,First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆市第五人民医院内分泌科,400062 [2]重庆市第五人民医院心血管内科,400062 [3]重庆医科大学附属第一医院内分泌科,400016

出　　处：《重庆医学》2020年第20期3399-3403,共5页Chongqing medicine

基　　金：重庆市技术创新与应用发展专项面上项目(cstc2019 jscx-msxm0546);重庆市留学人员创业创新支持计划项目(cx2019032);重庆市科卫联合医学科研项目(2018GDRC004);“重庆市中青年医学高端后备人才”培训项目(渝卫人〔2015〕49号)。

摘　　要：目的探讨新诊断青年2型糖尿病患者的相关影响因素。方法收集2017年12月至2018年6月在重庆市第五人民医院内分泌科住院的新诊断2型糖尿病患者157例为研究对象,以联合国教科文组织青年定义标准,即年龄45岁为切点分为青年组60例、中老年组97例。比较分析新诊断青年2型糖尿病患者的常规生化指标,以探索相关影响因素。结果本研究发现,青年组男性比例、体重指数(BMI)、空腹葡萄糖(FPG)、血清总胆固醇(TC)、三酰甘油(TG)、尿酸(UA)均高于中老年组,而高密度脂蛋白胆固醇(HDL-C)、总胆汁酸(TBA)均低于中老年组,差异有统计学意义(P<0.05)。Spearman相关分析发现,新诊断2型糖尿病青年发病与男性(r=0.199,P=0.013)、TC(r=0.159,P=0.048)、TG(r=0.253,P=0.001)、UA(r=0.298,P=0.000)呈正相关,与TBA(r=-0.226,P=0.005)、HDL-C(r=-0.176,P=0.029)呈负相关。二元Logistic回归分析发现,TG(OR=1.978,95%CI:1.068~3.662,P=0.030)、UA(OR=1.004,95%CI:1.000~1.009,P=0.039)增加了新诊断2型糖尿病青年发病的风险,TBA(OR=0.509,95%CI:0.283~0.913,P=0.024)使2型糖尿病青年发病的风险降低了49.1%。结论TG和UA可能是新诊断青年2型糖尿病患者的独立危险因素,而TBA可能是其独立保护因素。Objective To investigate the influencing factors in youth patients with newly diagnosed type-2 diabetes mellitus(T2DM).Methods A total of 157 patients with newly diagnosed T2DM in the endocrinology department of Chongqing Municipal Fifth People′s Hospital from December 2017 to June 2018 were selected as the study subjects and divided into the youth group(60 cases)and middle aged and elderly group(97 casesd)according to the youth definition criterion by UNESCO.The routine biochemical indexes were analyzed and compared among young adult patients with newly diagnosed T2DM and the related influencing factors were investigated.Results This study found that the male proportion,body mass index(BMI),fasting plasma glucose(FPG),serum total cholesterol(TC),total triglyceride(TG)and uric acid(UA)in the young group were higher than those in the middle aged and elderly group,while the levels of high density lipoprotein cholesterol(HDL-C)and total bile acid(TBA)were lower than those in the middle aged and elderly group.The Spearman correlation analysis found that the onset of youth patients with newly diagnosed T2DM was positively correlated with male(r=0.199,P=0.013),TC(r=0.159,P=0.048),TG(r=0.253,P=0.001)and UA(r=0.298,P=0.000),and negatively correlated with TBA(r=-0.226,P=0.005)and HDL-C(r=-0.176,P=0.029).The binary Logistic regression analysis showed that TG(OR=1.978,95%CI:1.068-3.662,P=0.030)and UA(OR=1.004,95%CI:1.000-1.009,P=0.039)increased the onset risk of youth patients with newly diagnosed T2DM,and TBA(OR=0.509,95%CI:0.283-0.913,P=0.024)decreased the onset risk of youth patients with T2DM by 49.1%.Conclusion TG and UA may be the independent risk factors of youth patients with newly diagnosed T2DM,while TBA may be an independent protective factor.

关 键 词：青年 新诊断2型糖尿病 影响因素 

分 类 号：R587.1[医药卫生—内分泌]