孕妇血清轻稀土元素与小于胎龄儿的关联研究  

The association between serum light rare earth elements in pregnant women and small for gestational age birth

作　　者：闫会娜 闫赖赖[3] 张乐[1,2] 张亚黎[1,2] 庞一鸣 郝永秀 王斌[1,2] 李智文[1,2] 叶荣伟[1,2] YAN Huina;YAN Lailai;ZHANG Le;ZHANG Yali;PANG Yiming;HAO Yongxiu;WANG Bin;LI Zhiwen;YE Rongwei(Department of Epidemiology and Biostatistics, Institute of Reproductive and Child Health, School of Public Health, Peking University, Beijing 100191, China)

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,北京100191 [2]北京大学生育健康研究所,北京100191 [3]北京大学公共卫生学院卫生检验学系,北京100191

出　　处：《中国生育健康杂志》2020年第6期501-505,511,共6页Chinese Journal of Reproductive Health

基　　金：国家自然科学基金(81673177,41771527)。

摘　　要：目的研究孕妇血清中轻稀土元素含量与小于胎龄儿的关联性。方法研究对象来自2009—2013年在山西省寿阳县和平定县建立的孕期研究队列。采用巢式病例对照研究设计,纳入小于胎龄儿组126人,对照组381人。采用电感耦合等离子体质谱仪定量分析血清中稀土元素含量。结果孕期血清各轻稀土元素及轻稀土元素总量与小于胎龄儿发生风险的关联性均不具有统计学意义。根据采血日期分层分析结果显示孕早期镧、铈、镨、钐、铕与小于胎龄儿发生风险的关联性不具有统计学意义,钕元素与小于胎龄儿(粗OR=1.85;95%CI:1.06~3.25)、轻稀土元素总量与小于胎龄儿(粗OR=2.19;95%CI:1.24~3.88)具有统计学意义,调整其他混杂因素后其关联性不具有统计学意义;孕中期血清各稀土元素及轻稀土元素总量与小于胎龄儿的关联性均不具有统计学意义。结论本研究未发现孕妇血清中轻稀土元素与小于胎龄儿发生风险的关联性。Objective To investigate the associations between rare earth elements(REEs)in serum among pregnant women and small for gestational age birth(SGA).MethodsThe subjects were from the pregnancy cohort established in Shouyang County and Pingding County of Shanxi Province from 2009 to 2013.A nested case-control study design was used,a total of 126 SGA infants and 381 control subjects were included.The content of rare earth elements in serum was determined by inductively coupled plasma mass spectrometry(ICP-MS).ResultsThere was no significant correlation between serum light REEs and the risk of SGA.When stratified by sampling time,the crude odds ratio between neodymium and SGA was 1.85(95%CI:1.06-3.25),and the crude odds ratio between all light REEs and SGA was 2.19(95%CI:1.24-3.88)in the first trimester.After adjusting for other confounders,there were no significant associations between light REEs and SGA.No significant associations were observed between lights REEs in the second trimester and SGA.ConclusionNo significant association was found between light REEs in mother′s serum and risk of SGA.

关 键 词：轻稀土元素 血清 小于胎龄儿 

分 类 号：R71[医药卫生—妇产科学]