无过渡金属参与下Selectfluor作为“无氟”官能化试剂在有机合成中的应用  

Selectfluor as “Fluorine-Free” Functional Reagent Applied to Organic Synthesis under Transition Metal-Free Conditions

作　　者：孔瑶蕾 孙晓彤 翁建全[1] Kong Yaolei;Sun Xiaotong;Weng Jianquan(College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014)

机构地区：[1]浙江工业大学化学工程学院,杭州310014

出　　处：《有机化学》2020年第9期2641-2657,共17页Chinese Journal of Organic Chemistry

基　　金：浙江省自然科学基金(No.LY17C140003)资助项目。

摘　　要：Selectfluor是一种性能优越的商品化的亲电氟化试剂,广泛应用于氟化反应中.近年来Selectfluor作为"无氟"官能化试剂在有机合成中得到较广泛的应用,尤其是利用Selectfluor与过渡金属的协同催化体系催化反应,取得了较大的进展.然而,该催化体系存在过渡金属价格昂贵、污染环境等问题.因此,Selectfluor作为"无氟"官能化试剂在无过渡金属参与下的应用受到越来越多的关注.根据反应类型综述了无过渡金属参与下Selectfluor作为"无氟"官能化试剂在有机合成中的应用,并对其前景进行了展望.Selectfluor,a commercial electrophilic fluorination reagent with superior performance,is widely used in fluorination reactions.In recent years,Selectfluor has also been widely applied as"fluorine-free"functional reagent in organic synthesis.Especially the application of Selectfluor/transition metals synergetic catalytic system has made great progress.However,this catalytic system has some disadvantages,such as the use of expensive transition metals and environmental unfriendliness.Therefore,more and more attention has been paid to the application of Selectfluor as"fluorine-free"functional reagent under transition metal-free conditions.In this paper,classified by the type of reactions,the research progress of Selectfluor as a"fluorine-free"functional reagent in organic synthesis under transition metal-free conditions is reviewed,and their future outlook is also discussed.

关 键 词：SELECTFLUOR “无氟”官能化试剂 无过渡金属 有机合成 

分 类 号：O621.3[理学—有机化学]