特纳综合征与耳部疾患的相关性研究进展  

Progress in Research on Relationship between Turner Syndrome and Ear Diseases

作　　者：熊莹 司瑜[1] 张志钢[1] XIONG Ying;SI Yu;ZHANG Zhigang(Department of Otolaryngology Head and Neck Surgery,Sun Yat-Sen Memorial Hospital,Institute of Hearing and Speech-Language Science,Sun Yat-sen University,Guangzhou,510120,China)

机构地区：[1]中山大学孙逸仙纪念医院耳鼻咽喉头颈外科,中山大学听力与语言学研究所,广州510120

出　　处：《中华耳科学杂志》2020年第5期977-981,共5页Chinese Journal of Otology

基　　金：国家自然基金项目,项目编号:81371082;国家自然基金项目,项目编号:81670921;青年科学基金项目,项目编号:81600794。

摘　　要：特纳综合征(Turner Syndrome, TS)是X性染色体数目异常或结构畸变所导致的性染色体疾病。其核型可分为:单一型、嵌合型、X染色体结构异常、含Y染色体核型。身材矮小和第二性征发育障碍为其主要临床表现。近期研究发现,分泌性中耳炎、胆脂瘤、听力损失等耳部疾患也是其特征性临床表现之一,且发病率明显高于正常人,不同核型之间耳部疾患发病率也存在差异。故将耳部疾患与TS之间的相关性研究进展做一综述,以指导临床对TS的早期诊断及对其并发症的早期干预。Turner Syndrome(TS)is a sex chromosome disease caused by complete or partial absence of one X chromosome.Its karyotype can be divided into 4 categories:monosomy,mosaic karyotypes,X-chromosome structure abnormality and containing Y chromosome.The prominent features of TS are short stature and gonadal dysgenesis.Recent studies have found that secretory otitis media,cholesteatoma,hearing loss and other ear diseases are also among its characteristic clinical manifestations,with incidence rates that are significantly higher than in normal people.There are differences in ear diseases incidence among different karyotypes.Therefore,a review of the relationship between ear diseases and TS was conducted to guide early diagnosis of TS and early intervention for its complications.

关 键 词：TS 分泌性中耳炎 胆脂瘤 听力损失 治疗 

分 类 号：R764[医药卫生—耳鼻咽喉科]