盐敏感性高血压钠代谢相关基因的研究进展  

Advances in sodium metabolism-related genes in salt-sensitive hypertension

作　　者：曹镌文(综述) 尹新华(审校)[1] CAO Juanwen;YIN Xinhua(Eighth Ward of Cardiovascular Medicine,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院心血管内科第八病房,哈尔滨150001

出　　处：《临床与病理杂志》2020年第10期2721-2726,共6页Journal of Clinical and Pathological Research

基　　金：国家自然科学基金(81570437)。

摘　　要：我国血压正常的成年人群中盐敏感性的检出率为15%~42%,而合并高血压的人群盐敏感性,即盐敏感性高血压(salt-sensitive hypertension,SSH)检出率为28%~74%。SSH人群基数大,但至今尚缺乏特异性及一致性的测定标准。盐敏感性相关基因的发现为SSH的测定提供了更加科学的依据。研究表明,盐敏感性与高血压的发病机制均与肾钠代谢紊乱密切相关。In China,the detection rate of salt sensitivity in normotensive adult population is 15%–42%,while the detection rate of salt sensitivity in the population with hypertension is 28%–74%,that is salt-sensitive hypertension(SSH).There are a number of SSH patients,but there is still a lack of specific and consistent measurement standards.The discovery of salt-sensitive genes provides a more scientific basis for the determination of SSH.Studies have shown that both salt sensitivity and the pathogenesis of hypertension are closely related to the disorder of renal sodium metabolism.

关 键 词：盐敏感性高血压 基因 表观遗传学 

分 类 号：R54[医药卫生—心血管疾病]