大同地区孕产妇B族链球菌带菌情况及对妊娠结局的影响  

Prevalence of group B streptococcus in Datong area and the impact on pregnancy outcomes

作　　者：刘英 杨霞 吴植红 Liu Ying;Yang Xia;Wu Zhihong(Central Laboratory,the First People’s Hospital of Datong,Datong 037000)

机构地区：[1]山西省大同市第一人民医院中心实验室,037000 [2]山西省大同市第一人民医院产科六病区,037000

出　　处：《中国现代医药杂志》2020年第10期5-8,共4页Modern Medicine Journal of China

基　　金：大同市重点研发计划项目(编号:2018069)。

摘　　要：目的探讨孕产妇B族链球菌(GBS)感染对妊娠结局的影响。方法选择2018年10月~2019年9月在我院产检及分娩的897例妊娠妇女作为研究对象,在孕37~41周采用荧光定量PCR技术对其阴道和肛门分泌物的GBS进行检测。GBS阳性妊娠妇女57例作为阳性组(n=57),同期产检的840例正常妊娠妇女为阴性组(n=840)。对比分析两组孕妇情况(年龄、妊娠情况以及流产次数)和妊娠结局(早产、胎膜早破、宫内窘迫、宫内感染、产后出血)以及新生儿出生结局(新生儿肺炎、新生儿窒息、败血症、脑膜炎)。结果897例研究对象中GBS阳性者57例,感染率为6.35%。年龄≥35岁和<35岁孕妇的GBS阳性率分别为6.25%、6.38%,初产妇和经产妇的GBS阳性率分别为6.31%、6.73%,流产次数≥3次和<3次孕妇的GBS阳性率分别为7.94%、6.24%,差异无统计学意义(P>0.05)。阳性组孕妇胎膜早破、宫内窘迫、宫内感染、产后出血的发生率(31.58%、3.51%、1.75%、5.26%)均高于阴性组(11.79%、0.71%、0.12%、1.31%),差异有统计学意义(P<0.05)。但阳性组早产的发生率(3.51%)与阴性组(0.95%)相比,差异无统计学意义(P>0.05)。阳性组新生儿肺炎、新生儿窒息、败血症发生率(10.53%、8.77%、10.53%)均高于阴性组(3.93%、1.07%、1.67%),差异有统计学意义(P<0.05)。结论孕产妇B族链球菌感染对妊娠结局及新生儿造成不良影响,临床应重视围产期妇女B族链球菌检测并预防用药,减少不良妊娠结局的发生。Objective To investigate the effect of group B streptococcus infection on pregnancy outcomes in pregnant women.Methods 897 pregnant women examined and delivered for GBS infection in our hospital from Oct 2018 to Sep 2019 were taken as the study object.At 37~41 weeks of gestation,GBS of vaginal and anal secretions was detected by fluorescent quantitative PCR technology.57 GBS positive pregnant women were included in the positive group(n=57),and 840 normal pregnant women who were examined during the same period were selected in the negative group(n=840).The pregnant women(age,pregnancy and number of miscarriages)and pregnancy outcomes (premature delivery,premature rupture of membranes,intrauterine distress,intrauterine infections postpartum hemorrhage) and neonatal outcomes(neonatal pneumonia,neonatal asphyxia,sepsis,meningitis)were compared.Results Among 897 cases,57 cases were GBS positive,the infection rate was 6.35%.The positive rate of pregnant women whose age were≥35 and<35 years was 6.25%and 6.38%,respectively.The GBS-positive rate of primiparous and menstrual women was 6.31%and 6.73%.The positive rate of GBS in pregnant women with≥3 abortions and<3 abortions was 7.94%and 6.24%,respectively,and the difference was not statistically significant(P>0.05).The incidence of premature rupture of membranes,intrauterine distress,intrauterine infections and postpartum hemorrhage in the positive group(31.58%,3.51%,1.75%,5.26%)were higher than those in the negative group(11.79%,0.71%,0.12%,1.31%),and the differences were statistically significant(P<0.05).However,the incidence of premature delivery in the positive group(3.51%)was not significantly different from that in the negative group(0.95%).The incidence of neonatal pneumonia,neonatal asphyxia and sepsis(10.53%,8.77%,10.53%)in positive group was higher than that in the negative group(3.93%,1.07%,1.67%),and the differences were statistically significant.Conclusion Group B streptococcal infection may cause adverse effect on pregnancy outcomes.We should pay attentio

关 键 词：GBS感染 B族链球菌 妊娠结局 

分 类 号：R714.25[医药卫生—妇产科学]