瘦素和瘦素受体基因多态性与妊娠期糖尿病易感性的相关性研究  

Association between Leptin Gene,Leptin Receptor Gene Polymorphism and Susceptibility of Gestational Diabetes Mellitus

作　　者：向俊 邓梦瑶 唐昭 周伽 向兵[1] 曾婧[1] 易晶 杨梅[1] Xiang Jun;Deng Mengyao;Tang Zhao(Department of Maternal,Child and Adolescent Health,School of Medicine,Wuhan University of Science and Technology,Wuhan 430065,China)

机构地区：[1]武汉科技大学医学院儿少卫生与妇幼保健学系,武汉430065

出　　处：《华中科技大学学报（医学版）》2020年第5期630-633,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目(No.81703239)。

摘　　要：目的研究瘦素及其受体基因多态性与妊娠期糖尿病(GDM)易感性的关系,为妊娠期糖尿病的发病机制研究和制定其预防策略提供线索。方法采用MassArray基因分析平台检测862名GDM患者和893名葡萄糖耐量正常的孕妇的3个基因多态性位点(瘦素基因rs2167270,瘦素受体基因rs1805096、rs1137100),应用非条件Logistic回归模型分析基因多态性与GDM发病风险的关系。结果经模型调整后,携带瘦素基因rs2167270位点GA基因型的孕妇GDM发病风险是GG携带者的1.69倍(OR=1.69,95%CI:1.20~2.38,P=0.003)。未发现瘦素受体基因rs1805096、rs1137100与GDM易感性相关(均P>0.05)。结论瘦素基因rs2167270位点多态性与GDM易感性有关。Objective To investigate the relationship between leptin gene,leptin receptor gene polymorphism and susceptibility of gestational diabetes mellitus(GDM),and to provide evidence for exploring the pathogenesis and prevention strategies of GDM.Methods MassArray gene analysis platform was used to detect 3 gene polymorphism loci(rs2167270 of leptin gene,rs1805096 and rs1137100 of leptin receptor gene)in 862 patients with GDM and 893 pregnant women with normal glucose tolerance.And the unconditional logistic regression model was used to analyze the relationship between gene polymorphism and the risk of GDM.Results After model adjustment,pregnant women with leptin gene rs2167270 GA genotype was 1.69 times more likely to develop GDM than carriers with GG genotype(OR=1.69,95%CI:1.20-2.38,P=0.003).And the susceptibility of GDM was not associated with leptin receptor gene rs1805096 or rs1137100(all P>0.05).Conclusion Leptin gene rs2167270 polymorphism is associated with the susceptibility of GDM.

关 键 词：瘦素基因 瘦素受体基因 基因多态性 妊娠期糖尿病 

分 类 号：R714.256[医药卫生—妇产科学]