CD73在皮肤恶性黑素瘤中的表达  

Expression of CD73 in human malignant melanoma

作　　者：栾春艳[1] 邓丹琪[1] 周晓鸿[1] 李文华[1] LUAN Chun-yan;DENG Dan-qi;ZHOU Xiao-hong;LI Wen-hua(Second Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650101)

机构地区：[1]昆明医科大学第二附属医院皮肤性病科,云南昆明650101

出　　处：《皮肤病与性病》2020年第5期627-629,共3页Dermatology and Venereology

基　　金：云南省卫生科技计划项目(2017NS313)。

摘　　要：目的探讨CD73在皮肤恶性黑素瘤、良性痣中的表达及意义。方法免疫组化方法检测10例正常皮肤、20例皮肤恶性黑素瘤及20例皮肤良性痣皮损石蜡包埋标本中CD73的表达情况。结果CD73在良性痣和恶性黑素瘤中的阳性表达率显著高于正常皮肤(P<0.001)。CD73在良性痣和恶性黑素瘤中阳性表达率及表达强度无差异(P>0.0167)。结论CD73在皮肤恶性黑素瘤中表达明显增强,可能参与了恶性黑素瘤的发生;CD73在恶性黑素瘤及良性痣中表达无差异。Objective To investigate the expression and significance of CD73 in human malignant melanoma and benign sputum.Methods Immunohistochemistry was used to detect the expression of CD73 in 10 normal human skin,20 malignant melanoma and 20 benign skin lesions.Results The expression of CD73 in benign sputum and malignant melanoma was significantly different from that in normal human skin(P<0.001).The positive expression and intensity of CD73 in benign sputum and malignant melanoma were not statistically significant(P>0.0167).Conclusion The expression of CD73 was significantly increased in malignant melanoma,which may be involved in the occurrence and development of malignant melanoma.There was no difference in the expression of CD73 in malignant melanoma and benign sputum.

关 键 词：胞外5’-核苷酸酶(CD73) 恶性黑素瘤 良性痣 

分 类 号：R715.02[医药卫生—妇产科学] R739.5[医药卫生—临床医学]