夹脊穴加疱疹区皮内注射疼痛液联合加巴喷丁治疗带状疱疹后遗疼痛的研究  

Jiaji point plus intradermal injection of pain solution in herpes zoster area combined with gabapentin in the treatment of postherpetic pain

作　　者：黄伟[1] 韦春燕 陆华勇[1] 兰志勇[1] 谭周宏 莫世芬 韦俊梅 HUANG Wei;WEI Chun-yan;LU Hua-yong;LAN Zhi-yong;MO Shi-fen;WEI Jun-mei(Department of Dermatology,The Third people's Hospital of Hechi,Hechi,Guangxi 547000)

机构地区：[1]广西河池市第三人民医院皮肤科,广西河池547000

出　　处：《皮肤病与性病》2020年第5期638-641,共4页Dermatology and Venereology

基　　金：河池市科技成果转化与应用科研课题(河科B1824-32)。

摘　　要：目的研究采用夹脊穴加疱疹区皮内注射疼痛液联合加巴喷丁治疗带状疱疹后遗神经疼痛的效果。方法将入组的90例PHN患者随机分为A、B、C三组,每组30例。其中,A组口服加巴喷丁胶囊治疗;B组在A组的基础上,加行夹脊穴注射疼痛液治疗;C组在A组的基础上,行夹脊穴注射和疱疹区注射疼痛液治疗。随访治疗前和治疗后,记录三组患者的疼痛情况(visual analogue scale,VAS)、失眠情况(pittsbugh sleep quality index,PSQI),并进行统计学分析。结果三组VAS评分、PSQI评估比较,A、B、C三组在T1至T4时间点的疼痛VAS评分、PSQI评估均显著低于同组T0时间点(P<0.001),但C组较A、B组更优,差异有统计学意义(P<0.001);三组在T1、T2、T3、T4相同时间点的疼痛VAS评分、PSQI评估比较,C组显著优于A、B两组,差异有统计学意义(P<0.001);三组间比较,C组VAS、PSQI改善情况均优于A组、B组(P<0.001)。结论夹脊穴加疱疹区皮内注射疼痛液联合加巴喷丁治疗在改善PHN患者疼痛、失眠方面效果显著,近远期疗效均优于单独口服加巴喷丁、单独口服加巴喷丁和夹脊穴注射疼痛液治疗。Objective To study the effect of Jiaji point plus intradermal injection of pain solution in herpes zoster area combined with gabapentin in the treatment of postherpetic neuralgia.Methods 90 PHN patients were randomly divided into three groups:group A,group B and group C,30 cases in each group.Among them,group A was treated by oral injection of gabapentin capsule;group B was treated by injection of pain solution into Jiaji point on the basis of group A;group C was treated by injection of pain solution into Jiaji point and herpes area on the basis of group A.Before and after treatment,the pain(VAS)and insomnia(PSQI)were recorded.And statistical analysis was performed.Results Compared with the VAS score and PSQI evaluation of the three groups,the pain VAS score and PSQI evaluation of the three groups from T1 to T4 were significantly lower than that of the same group at T0 time point(P<0.001),and group C was statistically significant better than group A and B(P<0.001);compared with the pain VAS score and PSQI evaluation of the three groups at the same time point of T1,T2,T3 and T4,and group C was statistically significant better than group A and B(P<0.001).The improvement of VAS and PSQI in group C was better than that in group A and B(P<0.001).Conclusion Jiaji point plus intradermal injection of pain liquid in herpes area combined with gabapentin in the treatment of PHN has a significant effect in improving pain and insomnia,and the short-term and long-term effects are better than that of Jiaji point alone plus gabapentin and Jiaji point alone.

关 键 词：夹脊穴 疱疹区 疼痛液 加巴喷丁 带状疱疹后神经痛 

分 类 号：R4[医药卫生—临床医学] R78