系统性接触性皮炎发病机制及诊治研究进展  

Update on pathogenesis,diagnosis and treatment of systemic contact dermatitis

作　　者：徐静 黄玲 XU Jing;HUANG Ling(Department of Dermatology,The First Affiliated Hospital of Dali University,Dali,Yunnan 671000)

机构地区：[1]大理大学第一附属医院皮肤科,云南大理671000

出　　处：《皮肤病与性病》2020年第5期668-671,共4页Dermatology and Venereology

基　　金：云南省教育厅科学研究基金(2019Y0283)。

摘　　要：系统性接触性皮炎(SCD)是指已具有接触致敏的个体,当半抗原通过口服、透皮、静脉注射或吸入进入机体到达皮肤而发生的一种炎症性皮肤病。研究发现Ⅳ型、Ⅲ型、Ⅰ型超敏反应可能参与其发病。由于过敏原的种类和数量、致敏途径及变态反应的类型不尽相同,SCD临床表现多样。笔者对SCD发病机制、临床表现及诊治进行综述,旨在为SCD的进一步研究提供参考。Systemic contact dermatitis(SCD)is an inflammatory skin disease that occurs when an individual sensitized to a contact allergen is exposed to that same allergen or a cross-reacting molecule through a systemic route.Systemic exposure to allergens can include transcutaneous,transmucosal,oral,intravenous,intramuscular,and inhalational routes.It was found that type IV,type III and type I hypersensitivity may be involved in the pathogenesis.Due to the different types and quantities of allergens,sensitization pathways and types of allergic reactions,SCD may have a variety of clinical manifestations and skin lesions.The update on the pathogenesis,clinical manifestations,diagnosis and treatment of systemic contact dermatitis are reviewed in this paper.The purpose is to provide reference for further research of SCD.

关 键 词：系统性接触性皮炎 狒狒综合征 发病机制 诊治 

分 类 号：R751.02[医药卫生—皮肤病学与性病学] R758.22[医药卫生—临床医学]