Mechanism underlying treatment of ischemic stroke using acupuncture:transmission and regulation  

作　　者：Bing-Qian Cao Feng Tan Jie Zhan Peng-Hui Lai 

机构地区：[1]Department of Neurology,Foshan Hospital of Traditional Chinese Medicine,Guangzhou University of Chinese Medicine,Foshan,Guangdong Province,China [2]Department of Rehabilitation,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou,Guangdong Province,China [3]Department of Rehabilitation,Nan’ao People’s Hospital Dapeng New District,Shenzhen,Guangdong Province,China

出　　处：《Neural Regeneration Research》2021年第5期944-954,共11页中国神经再生研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China,Nos.81072947,81473470,81774423,the Natural Science Foundation of Guangdong Province of China,No.2014A030311033(all to FT).

摘　　要：The inflammatory response after cerebral ischemia/reperfusion is an important cause of neurological damage and repair.After cerebral ischemia/reperfusion,microglia are activated,and a large number of circulating inflammatory cells infiltrate the affected area.This leads to the secretion of inflammatory mediators and an inflammatory cascade that eventually causes secondary brain damage,including neuron necrosis,blood-brain barrier destruction,cerebral edema,and an oxidative stress response.Activation of inflammatory signaling pathways plays a key role in the pathological process of ischemic stroke.Increasing evidence suggests that acupuncture can reduce the inflammatory response after cerebral ischemia/reperfusion and promote repair of the injured nervous system.Acupuncture can not only inhibit the activation and infiltration of inflammatory cells,but can also regulate the expression of inflammation-related cytokines,balance the effects of pro-inflammatory and anti-inflammatory factors,and interfere with inflammatory signaling pathways.Therefore,it is important to study the transmission and regulatory mechanism of inflammatory signaling pathways after acupuncture treatment for cerebral ischemia/reperfusion injury to provide a theoretical basis for clinical treatment of this type of injury using acupuncture.Our review summarizes the overall conditions of inflammatory cells,mediators,and pathways after cerebral ischemia/reperfusion,and discusses the possible synergistic intervention of acupuncture in the inflammatory signaling pathway network to provide a foundation to explore the multiple molecular mechanisms by which acupuncture promotes nerve function restoration.

关 键 词：ACUPUNCTURE central nervous system factor inflammation ischemic stroke PATHWAYS protein STROKE 

分 类 号：R246.6[医药卫生—针灸推拿学]