DKI多定量参数与子宫内膜癌患者增殖抗原Ki-67表达的相关性研究  

Correlation Between Multiple Quantitative Parameters of DKI and Expression of Proliferating Antigen Ki-67 in Patients with Endometrial Cancer

作　　者：张亚[1] 何丽萍[1] 张顺[2] 周波 杨英捷[1] ZHANG Ya;HE Li-ping;ZHANG Shun(Department of Gynecological Tumor Surgery,Guizhou Tumor Hospital,Guiyang 550001,Guizhou Province,China)

机构地区：[1]贵州省肿瘤医院妇瘤外科,贵州贵阳550001 [2]贵州省肿瘤医院影像科,贵州贵阳550001

出　　处：《中国CT和MRI杂志》2020年第12期89-92,共4页Chinese Journal of CT and MRI

摘　　要：目的研究分析扩散峰度成像(DKI)多定量参数与子宫内膜癌患者增殖抗原Ki-67表达水平的相关性。方法选取2017年1月至2018年12月我院妇瘤外科手术病理确诊为子宫内膜癌患者103例为研究对象,根据患者增殖抗原Ki-67表达水平进行分组,其中增殖抗原Ki-67表达水平低于50%的53例患者为低表达组,增殖抗原Ki-67表达水平大于等于50%的50例患者作为高表达组,记录并比较两组患者病灶实质区DKI各个参数值。结果高表达组患者的MK、Ka及Kr值明显大于低表达组,差异具有统计学意义(P<0.05);MD、Da及Dr值明显小于低表达组,差异具有统计学意义(P<0.05);比较两组患者的FAK和FA值差异不具有统计学意义(P>0.05)。DKI各参数中MK、Ka、Kr、MD、Da以及Dr值与Ki-67表达水平高低具有明显鉴别诊断价值。DKI参数中MK、Ka以及Kr值与Ki-67表达水平呈正相关关系,差异具有统计学意义(P<0.05);DKI参数中MD、Da以及Dr值与Ki-67表达水平呈负相关关系,差异具有统计学意义(P<0.05);DKI参数中FAK以及FA值与Ki-67表达水平无相关关系,差异不具有统计学意义(P>0.05)。结论DKI参数中的MK、Ka、Kr、MD、Da、Dr值与子宫内膜癌患者增殖抗原Ki-67的表达水平具有一定相关性,能够有效反映子宫内膜癌患者肿瘤细胞增殖程度,其中MK值为DKI参数中的最佳参数。Objective To investigate the correlation between multiple quantitative parameters of Diffusion Kurtosis Imaging(DKI)and the expression of proliferating antigen Ki-67 in patients with endometrial cancer.Methods A total of 103 patients with endometrial cancer diagnosed by gynecologic surgery in our hospital from January 2017 to December 2018 were divided into the low-expression group(n=53,expression<50%)and high-expression group expression(n=50,expression≥50%)according to the expression level of proliferating antigen Ki-67.The DKI parameters of the lesion parenchymal area were recorded and compared.Results The MK,Ka and Kr values of the high expression group were significantly higher than those of the low expression group(P<0.05);the MD,Da and Dr values were significantly lower than those of the low expression group(P<0.05).There was no statistically significant difference in FAK and FA between the two groups(P>0.05).The values of MK,Ka,Kr,MD,Da and Dr in the parameters of DKI and the expression level of Ki-67 have obvious differential diagnosis value.The MK,Ka and Kr values in DKI parameters were positively correlated with the expression level of Ki-67(P<0.05).There was a negative correlation between MD,Da and Dr values and Ki-67 expression in DKI parameters(P<0.05);there was no correlation between FAK and FA values and Ki-67 expression levels in DKI parameters(P>0.05).Conclusion The MK,Ka,Kr,MD,Da and Dr values in DKI parameters are correlated with the expression level of proliferating antigen Ki-67 in patients with endometrial cancer,which can effectively reflect the proliferation of tumor cells in patients with endometrial cancer,in which the MK value is the best parameter in the DKI parameters.

关 键 词：扩散峰度成像 子宫内膜癌 KI-67 

分 类 号：R445[医药卫生—影像医学与核医学] R737[医药卫生—诊断学]