利尿钠肽与代谢综合征的研究进展  

Natriuretic Peptide and Metabolic Syndrome

作　　者：樊德慧 金娟 韩宇博 田苗[1] 刘莉 FAN Dehui;JIN Juan;HAN Yubo;TIAN Miao;LIU Li(Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China;Department of Cardiology,The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中药大学附属第一医院心血管科,黑龙江哈尔滨150040

出　　处：《心血管病学进展》2020年第10期1074-1077,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金面上项目(81873284);黑龙江省博士后资助经费项目(LBH-Z18253);黑龙江中医药大学双一流及优势特色学科建设项目(HLJSYL1001);黑龙江中医药大学校科研基金科技创新团队项目(2019TD01);黑龙江中医药大学校科研基金博士创新项目(2019BS02)。

摘　　要：代谢综合征(MS)是一组以肥胖,血糖、血压和血脂异常为主要表现的全身代谢紊乱性综合征,其发病率逐年增高,已成为全球公共卫生问题,MS各组成要素均可增加心血管疾病及2型糖尿病的发病风险及死亡率,严重威胁着人类的健康,因此治疗MS已成为目前亟待解决的问题。利尿钠肽是由心脏、脑及血管内皮等分泌的肽类物质,主要分为心房钠尿肽、脑钠肽及C型利尿钠肽,具有利钠、利尿和舒张血管等作用。最新发现利尿钠肽还具有调节糖脂代谢的作用,在防治肥胖及MS中起到关键性的作用。现旨在通过探讨利尿钠肽与MS各组成要素的关系,为MS的治疗提供新思路。Metabolic syndrome(MS)is a group of systemic metabolic disorder syndrome with obesity,abnormal blood glucose,abnormal blood pressure and abnormal blood lipid.Its incidence is increasing year by year,which has become a global public health problem.All elements of MS can lead to an increase in the risk and mortality of cardiovascular disease and type 2 diabetes,which seriously threaten human health.Therefore,the treatment of MS has become an urgent problem.Natriuretic peptide is a kind of peptide secreted by the heart,brain and vascular endothelium.It is mainly divided into atrial natriuretic peptide,brain natriuretic peptide and C-type natriuretic peptide,which have diuretic,natriuretic,and vasodilatory properties.Recently,it was found that natriuretic peptide can also regulate the metabolism of glucose and lipid,and play a key role in the prevention and treatment of obesity and MS.The purpose of this paper is to provide new ideas for the treatment of MS by exploring the effect of natriuretic peptide on the components of MS.

关 键 词：利尿钠肽 代谢综合征 肥胖 胰岛素抵抗 心血管危险因素 

分 类 号：R589[医药卫生—内分泌]