Argentum 5-Hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one-6-sulfonate:Synthesis,Crystal Structure and Antitumor Activity  

作　　者：LI Wu-Wu ZHENG Min-Yan GAO Yi-Hong ZHANG Zun-Ting 李午戊;郑敏燕;高奕红;张尊听(College of Chemistry&Chemical Engineering,Xianyang Normal University,Xianyang 712000,China;Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry,National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China and School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi'an 710062,China)

机构地区：[1]College of Chemistry&Chemical Engineering,Xianyang Normal University,Xianyang 712000,China [2]Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry,National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China and School of Chemistry and Chemical Engineering,Shaanxi Normal University,Xi'an 710062,China

出　　处：《Chinese Journal of Structural Chemistry》2020年第10期1898-1905,1746,共9页结构化学（英文）

基　　金：Scientific Research Program Funded by Shaanxi Provincial Education Department(No.18JK0837);Natural Science Basic Research Plan Funded by Shaanxi Province of China(No.2018JM2045);Science and Technology Projects of Xianyang City(No.2017k02-19);Scientific Research Project Funded by Xianyang Normal University(No.XSYK18006);Qing-Lan Talents Project Funded by Xianyang Normal University(No.XSYQL201904)。

摘　　要：In order to improve the water solubility and bioavailability of 5-hydroxy-7-methoxyflavone,argentum 5-hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one-6-sulfonate[Ag4(H2O)6](C(16)H(11)O4SO3)4·H2O(1,C(16)H(11)O4SO3=5-hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one-6-sulfonate)was synthesized by sulfonation reaction.The structure of 1 was characterized by FT-IR,elemental analysis and X-ray single-crystal diffraction.Complex 1 belongs to the triclinic system,space group P1,a=8.077(4),b=12.365(4),c=17.735(7)A,V=1685.0(12)A3,Z=1,μ=1.372 mm^–1,Dc=1.936 g/cm^3,F(000)=984,the final R=0.0819 and wR=0.2332 with I>2σ(I).3D structure of 1 exhibits alternating organic and inorganic regions.O–H×××O hydrogen bonds and Ag–O coordination interactions exist among crystal water,coordinated water and sulfo group,which constructed an organic zone.Flavone skeletons form organic region of 1.Sulfo group is the bridge linking these two regions.The in vitro antitumor activity of 1 against human lymphoma cells U937 and human breast cancer cells MCF-7 were evaluated with CCK-8 assay.The result shows that 1 showed inhibitory activity against tumour cell U937 and MCF-7,and indicated that flavone sulfonate derivatives may be potential leads for further biological screenings and may generate drug-like molecules.

关 键 词：argentum 5-hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one-6-sulfonate sulfonation reaction crystal structure antitumor activity 

分 类 号：O641.4[理学—物理化学] TQ460.1[理学—化学]