田基黄化学成分研究  

Chemical Constituents of Hypericum japonicum

作　　者：朱伟 苑春茂[1,2] 曾艳荣 郝小江[1,2] 李亚男 ZHU Wei;YUAN Chun-mao;ZENG Yan-rong;HAO Xiao-jiang;LI Ya-nan(Guizhou Medical University,State Key Laboratory for Utilization and Development of Medicinal PlantResources,Guiyang 550014,China;Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences/Guizhou NaturalMedicine EngineeringResearch Center,Guiyang 550014,China)

机构地区：[1]贵州医科大学药用植物资源功效利用与开发国家重点实验室,贵州贵阳550014 [2]贵州省中国科学院天然产物化学重点实验室/贵州省天然药物工程研究中心,贵州贵阳550014

出　　处：《中药材》2020年第2期328-332,共5页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金资助项目(81502959);国家基金联合基金(U1812403)。

摘　　要：目的:对黔产田基黄中降血糖的活性成分进行研究。方法:采用硅胶色谱、Sephadex LH-20凝胶色谱及半制备HPLC等多种方法从田基黄提取物中分离单体化合物,利用MS、1H-NMR、13C-NMR等波谱数据分析鉴定化合物结构。结果:从田基黄的甲醇提取物中共分离得到11个化合物,分别鉴定为:白桦酸(1)、oleanolic acid 3-O-arabinoside(2)、齐墩果酸(3)、diospyrolide(4)、6-hydroxystigmast-4-en-3-one(5)、N-benzoyl-L-phenylalaninyl-N-benzoyl-L-phenylalaninate(6)、sampsone C(7)、wightianin(8)、isoferulic acid(9)、blumenol A(10)和apocynol A(11)。结论:其中,化合物2、4~6和11为首次从该属植物中分离得到,化合物3、7~10为首次从该植物中分离得到。Objective:To study the antidiabetic active constituents from Hypericum japonicum distributed in Guizhou.Methods:Silica gel chromatography,Sephadex LH-20 gel chromatography,semi-preparative HPLC and other methods were used to isolate compounds from the extracts of Hypericum japonicum,MS,1H-NMR,13C-NMR and other spectral data were used to analyze and identify structures.Results:Eleven compounds were isolated and identified as betulinic acid(1),oleanolic acid 3-O-arabinoside(2),oleanolic acid(3),diospyrolide(4),6-hydroxystigmast-4-en-3-one(5),N-benzoyl-L-phenylalaninyl-N-benzoyl-L-phenylalaninate(6),sampsone C(7),wightianin(8),isoferulic acid(9),blumenol A(10),apocynol A(11),respectively.Conclusion:Compounds 2,4 to 6,11 are isolated from Hypericum genus for the first time,compounds 3,7 to 10 are isolated from this plant for the first time.

关 键 词：田基黄 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]