奥司他韦治疗甲型H1N1流感的疗效及安全性评价  

Curative Effect and Safety of Oseltamivir on H1N1 Influenza

作　　者：刘学涵 LIU Xue-han(Department of Pharmacy,Nanyang Wancheng Maternal and Child Health Care Hospital,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳市宛城区妇幼保健院药房,河南南阳473000

出　　处：《罕少疾病杂志》2020年第6期51-52,共2页Journal of Rare and Uncommon Diseases

摘　　要：目的分析奥司他韦治疗甲型H1N1流感的疗效及安全性。方法选取2017年6月至2019年4月期间我院收治的86例甲型H1N1流感患者,根据治疗方法不同分为观察组(n=46)和对照组(n=40),对照组给予常规治疗,观察组在常规治疗上给予奥司他韦颗粒。评价两组临床疗效,观察两组体温恢复时间、症状改善时间、病毒核酸阳性持续时间,统计不良反应发生率。结果观察组总有效率(95.65%)高于对照组(75.00%),有显著差异(P<0.05)。观察组体温恢复时间、症状消失时间和病毒核酸阳性持续时间均短于对照组,有显著差异(P<0.05);两组的不良反应发生率无显著差异(P>0.05)。结论奥司他韦治疗甲型H1N1流感治疗效果佳,且安全性好。Objective To analyze curative effect and safety of oseltamivir on H1N1 influenza.Methods 86 patients with H1N1 influenza who were admitted to the hospital from June 2017 to April 2019 were enrolled.According to different treatment methods,they were divided into observation group(n=46)and control group(n=40).The control group was given routine treatment,while observation group was orally administered with oseltamivir capsules on this basis.The clinical curative effect of the two groups was evaluated.The temperature recovery time,symptom improvement time and duration of positive viral nucleic acid in both groups were observed.The incidence of adverse reactions was statistically analyzed.Results The total response rate of observation group was higher than that of control group(95.65%vs 75.00%)(P<0.05).The temperature recovery time,symptom disappearance time and duration of positive viral nucleic acid in observation group were shorter than those in control group(P<0.05).There was no significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion The curative effect of oseltamivir is good on H1N1 influenza,with high safety.

关 键 词：甲型HINI流感 奥司他韦 临床疗效 安全性 

分 类 号：R563.1[医药卫生—呼吸系统]