自体血液回输技术对颈椎手术患者的应用效果、免疫功能及凝血功能的影响  

Application effect of autologous blood transfusion technology and its effect on immune function and coagulation function in patients in colorectal cancer surgery

作　　者：阙彬[1] 饶春晖 万政佐[1] 梁志鹏[1] 陈欣[1] 周蓉[1] QUE Bin;RAO Chunhui;WAN Zhengzuo;LIANG Zhipeng;CHEN Xin;ZHOU Rong(Department of Anesthesiology,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou310007,China)

机构地区：[1]杭州市中医院麻醉科,浙江杭州310007

出　　处：《中国现代医生》2020年第27期110-113,共4页China Modern Doctor

基　　金：浙江省医学会临床科研基金项目(2016ZYC-A44);浙江省中医药科学研究基金项目(2020ZB155)。

摘　　要：目的分析自体血液回输技术在颈椎手术中的应用及对患者免疫功能及凝血功能的影响。方法纳入我院2017年4月~2019年4月收治的择期行颈椎手术估计术中出血量在400 mL以上的患者50例,依随机数字表法将患者分为对照组和试验组,每组各25例。对照组直接机器处理,试验组采纳先简易回收再机器处理,对比两组自体血洗涤前后血红蛋白、红细胞、红细胞压积(Hct)、2,3-二磷酸甘油酸(2,3-DPG)、白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)、干扰素-γ(IFN-γ)、自体血红细胞畸形率、回收率、免疫功能指标、携氧功能。结果两组患者术后第1天与第4天血红蛋白、红细胞、Hct、2,3-DPG水平比较,差异有统计学意义(P<0.05);术后第1天组间对比(P<0.05),术后第4天组间对比(P>0.05);两组患者术后第1天与第4天IL-1β、IL-8、IFN-γ水平比较,差异有统计学意义(P<0.05);术后第1天与第4天组间对比(P<0.05);两组患者自体血红细胞畸形率、回收率比较,差异有统计学意义(P<0.05);两组患者术后第1天与第4天的IgM、IgA、IgG水平比较,差异有统计学意义(P<0.05);术后第1天与第4天组间对比(P<0.05);试验组术后第1天与第4天PaO2、SaO2、pH值、RBC水平比较,差异有统计学意义(P<0.05);术后第1天组间对比(P<0.05),术后第4天组间对比(P>0.05)。结论简易自体血液回输技术对颈椎手术患者血红细胞的形态、携氧功能影响较小,不影响自体血红细胞畸形率、回收率,术后患者机体炎症反应较轻,免疫功能较高,值得借鉴。Objective To analyze the application of autologous blood transfusion technology in colorectal cancer surgery and its effect on patients'immune function and coagulation function.Methods A total of 120 patients with elective colorectal cancer surgery who were treated in our hospital from April 2017 to April 2019 were included.50 patients with elective colorectal cancer surgery who were estimated to have an intraoperative blood loss more than 400 mL were enrolled in our hospital from April 2017 to April 2019.The patients were divided into control group(n=25)and experimental group(n=25)according to the random number table method.The control group was processed directly with a machine.The experimental group adopted simple recovery and then was processed by machine.The hemoglobin,red blood cells,hematocrit(Hct),2,3-diphosphoglycerate(2,3-DPG),interleukin-1β(IL-1β),interleukin-8(IL-8),interferon-γ(IFN-γ),autologous red blood cell deformity rate,recovery rate,immune function index,oxygen carrying function in two groups before and after autologous blood washing were compared.Results There was a statistically significant difference in the levels of hemoglobin,red blood cells,Hct,2,3-DPG between the two groups on the 1st and 4th day after surgery(P<0.05);the comparison between the groups on the 1st day after surgery(P<0.05),the comparison between the groups on the 4th day after operation(P>0.05);the comparison of the levels of IL-1β,IL-8,and IFN-γbetween the two groups on the 1st day and the 4th day after the operation,the difference was statistically significant(P<0.05);comparison between the 1st and 4th day after operation(P<0.05);the autologous red blood cell malformation rate and recovery rate of the two groups of patients showed that the differences was statistically significant(P<0.05);Comparison of IgM,IgA,and IgG levels between 1st and 4th day after the operation,the difference was statistically significant(P<0.05);the comparison between the 1st and 4th day after the operation(P<0.05);the experimental group af

关 键 词：自体血液回输技术 颈椎手术 免疫功能 凝血功能 

分 类 号：R457.1[医药卫生—治疗学] R605[医药卫生—临床医学]