百令胶囊结合西医常规疗法治疗糖尿病肾病维持性腹膜透析临床研究  

Effect of Bailing capsule combined with western medicine on microinflammatory status in diabetic nephropathy patients with maintenance peritoneal dialysis

作　　者：张锐莹 蔡红丽[1] 扈瑞春[1] 岳英丽[1] Zhang Ruiying;Cai Hongli;Hu Ruichun;Yue Yingli(Department of Nephrology,the People’s Hospital of Langfang City,Langfang 065000,China)

机构地区：[1]河北省廊坊市人民医院肾内科,065000

出　　处：《国际中医中药杂志》2020年第8期737-740,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的评价百令胶囊结合西医常规疗法治疗DN维持性腹膜透析患者的临床疗效。方法将符合入选标准的2016年2月-2019年2月廊坊市人民医院行腹膜透析治疗的DN患者86例,按随机数字表法分为2组,每组43例。2组均给予持续性不卧床腹膜透析,对照组在此基础上结合西医常规疗法治疗,观察组在对照组基础上口服百令胶囊。2组均连续治疗3个月。采用全自动生化仪检测空腹血糖(fasting blood glucose,FPG),放射免疫法测定空腹胰岛素(fasting insulin,FINS),计算胰岛素抵抗指数(homeostasis model assessment insulin resistance index,HOMA-IR);采用ELISA法检测血清超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、IL-6、IL-17、TNF-α水平,采用生化分析仪检测患者SCr、BUN水平及24 h尿蛋白定量。结果治疗后,观察组血清FPG、FINS、HOMA-IR均低于对照组(t值分别为5.204、8.227、14.070,P值均<0.01);SCr、BUN、24 h尿蛋白定量均低于对照组(t值分别为5.022、5.900、5.246,P值均<0.01);血清hs-CRP、IL-6、IL-17、TNF-α水平均低于对照组(t值分别为12.871、7.021、7.733、8.165,P<0.01)。结论百令胶囊结合西医常规疗法可有效改善DN维持性腹膜透析患者的HOMA-IR和肾功能,减轻微炎症状态。Objective To investigate the efficacy of Bailing capsule combined with conventional western medicine on diabetic nephropathy patientswith maintenance peritoneal dialysis.Methods Eighty-six type 2 diabetic nephropathy patients receiving peritoneal dialysis in our hospital from February of 2016 to February of 2019 were selected and were divided into control group and observation group according to the random number table method with 43 cases in each group.All patients received continuous ambulatory peritoneal dialysis.Patients in the control group received routine treatment.In the observation group,patients took Bailing capsules based on the treatment of the control group.The two groups were treated continuously for 3 months.Insulin resistance(IR),fasting blood glucose(FPG),fasting insulin(FINS),renal function,and serum levels of microinflammatory factors high sensitivity c-reactive protein(hs-CRP),interleukin(IL)-6,IL-17,and tumor necrosis factor(TNF)-awere compared in the two groups.Results After the treatment,FPG,FINS,HOMA-IR,blood creatinine,urea nitrogen,and 24 h urinary protein in the observation group were significantly less than those of the control group(t value were 5.204,8.227,14.070,5.022,5.900,5.246,respectively,all Ps<0.01).After thetreatment,serum levels of hs-CRP,IL-6,IL-17,TNF-αin the observation group were significantly lower than those of the control group(t value were 12.871,7.021,7.733,8.165,respectively,all Ps<0.01).Conclusions Bailing capsule can effectively improve the insulin resistance and renal function of diabetic nephropathy patients during maintenance peritoneal dialysis and relieve the state of micro-inflammation.

关 键 词：糖尿病肾病 腹膜透析 持续不卧床 百令胶囊 中西医结合疗法 

分 类 号：R692.9[医药卫生—泌尿科学] R587.2[医药卫生—外科学]