虎杖主要化学成分及其生物合成机制研究进展  

Chemical constituents and their biosynthesis mechanisms of Polygonum cuspidatum

作　　者：张云婷 黄晓[1] 陈运中[1] 李军德[2] 余坤[1] ZHANG Yun-ting;HUANG Xiao;CHEN Yun-zhong;LI Jun-de;YU Kun(Hubei University of Chinese Medicine,Wuhan 430065,China;National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]湖北中医药大学,湖北武汉430065 [2]中国中医科学院中药资源中心,北京100700

出　　处：《中国中药杂志》2020年第18期4364-4372,共9页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划项目(2017YFC1701003)。

摘　　要：为深入了解虎杖中主要化学成分及其生物合成机制,该综述通过对近年来中外文献对虎杖主要化学成分进行分析的相关研究,梳理出虎杖的蒽醌类、萘醌类、二苯乙烯类、黄酮类、其他化合物等成分90余种,对其生物合成过程涉及的合成酶基因进行总结,并重点探讨虎杖二苯乙烯类、蒽醌类成分的生物合成机制。深入了解虎杖中主要化学成分的生物合成机制,以期为虎杖药材的品质提升及开发利用提供帮助。This article reviews the research progress of the chemical constituents and biosynthesis mechanisms of Polygonum cuspidatum.The chemistry components isolated from P.cuspidatum are mainly anthraquinones,naphthoquinones,stilbenes,flavonoids,and other compounds.The synthase genes involved in the biosynthesis process were summarized.The biosynthesis mechanism of stilbenes and anthraquinones was discussed.This article hopefully to provide a reference for further research,development and utilization of P.cuspidatum.

关 键 词：虎杖 化学成分 蒽醌类 白藜芦醇 生物合成 

分 类 号：R284.1[医药卫生—中药学] S567.1[医药卫生—中医学]