基于中西医临床病证特点的功能性消化不良动物模型分析  

Analysis of Animal Model of Functional Dyspepsia Based on Clinical Characteristics of Traditional Chinese Medicine and Western Medicine

作　　者：卢鹏飞 左艇[1] 苗明三[1] LU Peng-fei;ZUO Ting;MIAO Ming-san(Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学,郑州450046

出　　处：《中国实验方剂学杂志》2020年第18期210-215,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家国际合作基地项目(2016-65);河南省产学研项目(182107000029)。

摘　　要：基于功能性消化不良(FD)的中西医临床病证特点,对现有FD动物模型与临床标准吻合度分析评价,为完善FD动物模型提供思路和参考。通过罗列中西医消化不良的临床表现和诊断标准,符合西医临床诊断标准主要1项赋值11.7%,次要5%,符合中医诊断标准主证1项为15%,次证5%,对现有FD动物模型评分。分析结果发现高吻合度的有"高脂饲料喂养+番泻叶煎剂灌胃+束缚+游泳"联合干预,此法基本吻合FD中西医临床病证特点,不足在于造模因素偏多,缺乏控制可能诱发FD动物模型偏离。一般吻合度的有"灌胃碘乙酰胺联合小平台站""束缚""夹尾刺激",低吻合度的有"灌胃碘乙酰胺""胃部植入电极",以上方法均在一定程度上模拟出FD特点,但因素单一缺乏中医证候的体现。因此,联合运用多种单因素造模法,着重开发利用传统中药泻下药作造模药,控制造模进程,尝试制定一套FD动物造模期内各种干扰因素的时间部署表,不断优化动物模型评判标准,是今后完善FD模型的研究方向。Based on the clinical characteristics of functional dyspepsia(FD),this paper analyzes and evaluates the consistency between the existing FD animal models and the clinical standards,so as to provide ideas and references for improving the FD animal model.By listing the clinical manifestations and diagnostic criteria of dyspepsia in traditional Chinese and western medicine,this paper assessed the existing animal models of functional dyspepsia,which conformed to 11.7%of the main symptoms and 5%of the secondary symptoms in clinical diagnosis criteria in western medicine,and 15%of the main symptoms and 5%of the secondary symptoms in traditional Chinese medicine(TCM).The results showed that the high degree of anastomose was affected by"high fat feed+senna leaf decoction gavage+restraint+swimming".This method basically conformed with the clinical characteristics of FD in Chinese and western medicine.The deficiency lay in the large number of modeling factors and the lack of control,which might lead to FD model deviation.The average degree of conformity involved"gavage iodoacetamide combined with small platform station","binding"and"tail clamping stimulation",and the low degree of conformity involved"gavage iodoacetamide"and"stomach implanted electrode".The above methods simulated the characteristics of FD,but the single factor lacked the manifestation of TCM symptoms,which needed further improvement.Therefore,multiple single factor modeling methods were combined,with focus on the development and use of TCM purgative as modeling drug,so as to control the modeling process.An attempt shall be made to develop a set of time schedule of various interference factors during the modeling period of animals,in order to constantly optimize the evaluation criteria of animal models,which is the future study direction of improving FD models.

关 键 词：功能性消化不良 中西医 临床病证特点 动物模型 

分 类 号：R2-0[医药卫生—中医学] R22