中药汤剂对新型冠状病毒肺炎患者密切接触者预防作用的单臂研究  

A Single-Arm Study on the Preventive Effect of Chinese Medicine Decoction on Close Contacts of Patients with Coronavirus Disease 2019

作　　者：朱雪[1,2] 戴景超 沈宁[2] 郑建 王业震 高超[2] 何荣[2] 刘学 臧国栋 田梅[2] 贾新华[2] 张伟[2] ZHU Xue;DAI Jingchao;SHEN Ning;ZHENG Jian;WANG Yezhen;GAO Chao;HE Rong;LIU Xue;ZANG Guodong;TIAN Mei;JIA Xinhua;ZHANG Wei(Postdoctoral Station of Shandong University of Traditional Chinese Medicine,Jinan,250001;Affiliated Hospital of Shandong University of Traditional Chinese Medicine;Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine)

机构地区：[1]山东中医药大学博士后流动站,山东省济南市250001 [2]山东中医药大学附属医院 [3]山东中医药大学第二附属医院

出　　处：《中医杂志》2020年第20期1762-1766,共5页Journal of Traditional Chinese Medicine

基　　金：山东省重大科技创新工程(2020SFXGY04-1)。

摘　　要：目的评估中药预防汤剂对新型冠状病毒肺炎患者密切接触者的预防作用。方法对2020年2月9—18日在山东省内被诊断为新型冠状病毒肺炎患者密切接触者的人群发放代煎好的中药预防汤剂,自纳入之日起开始服用,连续服用5天。方剂组成:黄芪10g,麸炒白术10g,防风10g,忍冬藤15g,连翘10g,黄芩10g,北柴胡10g,清半夏6g,藿香10g,陈皮6g,茯苓15g,北沙参6g,生姜10g,采用煎药机煎药,每剂煎为2袋,每袋200ml,每日2袋,早晚各服用1袋,采用扫码登记的方式自愿填写服用信息。追踪隔离观察期14天密切接触者的核酸检测情况和发病情况,计算中药预防的有效率。结果截至2月18日,通过扫码登记服用的密切接触人员共有689例,来自山东省16个地市。其中男性392例(56.89%),女性297例(43.11%);年龄3~77岁,平均(27.91±14.80)岁。接触途径:1种接触途径者644例(93.47%),2种接触途径者36例(5.22%),3种接触途径者7例(1.02%),5种接触途径者2例(0.29%)。通过与山东省疾控中心截至3月3日的已报告的发病人群做比对,仅1例出现在其中,且此例为新型冠状病毒核酸检测阳性的无症状感染者。结论中药预防结合常规预防隔离措施对新型冠状病毒肺炎有较好的预防作用,建议在此类公共卫生事件中及时使用中药预防,可以有效降低密切接触者转为确诊患者的转化率。Objective To evaluate the preventive effect of Chinese medicine preventive decoction on close contacts of patients with coronavirus disease 2019(COVID-19).Methods Chinese medicine preventive decoction was applied to people who were judged to be close contacts of patients with COVID-19 in Shandong Province from February 9 to February 18,2020 on the date of inclusion.The patients took the decoction for 5 consecutive days.Prescription composition:Huangqi(Radix Astragali seu Hedysari)10 g,Baizhu(stir-fryed Rhizoma Atractylodis)10 g,Fangfeng(Radix Saposhnikoviae)10 g,Rendongteng(Caulis Lonicerae)15 g,Lianqiao(Fructus Forsythiae)10 g,Huangqin(Radix Scutellariae)10 g,Chaihu(Radix Bupleuri)10 g,Banxia(Rhizoma Pinelliae Preparata)6 g,Huoxiang(Herba Pogostemonis)10 g,Chenpi(Pericarpium Citri Reticulatae)6 g,Fuling(Poria)15 g,Beishashen(Radix Glehniae)6 g,Shengjiang(Rhizoma Zingiberis Recens)10 g,200 ml decoction per bag,2 bags a day,in the morning and evening.Scan code registration method was used to fill in the information voluntarily.The nucleic acid detection and disease status of close contacts was followed up during the 14-day isolation observation period,and the effective rate of the decoction prevention was calculated.Results Upto February 18,there were 689 close contacts from 16 cities in Shandong Province who registered and took the decoction by scanning the QR code.Among them,there were 392 males(56.89%)and 297 females(43.11%)aged from 3 to 77 years old,with an average of(27.91±14.80)years old.The exposure routes include 644 cases(93.47%)with one route of exposure,36 cases(5.22%)with two routes of exposure,7 cases(1.02%)with three routes of exposure,and 2 cases with five routes of exposure(0.29%).Comparing with the reported cases of the Shandong Provincial Center for Disease Control and Prevention upto March 3,only one case appeared among the list,and this case was an asymptomatic infection with a positive nucleic acid test for the COVID-19.Conclusion Chinese medicine prevention combined with conventional preven

关 键 词：新型冠状病毒肺炎 预防 中药汤剂 发病率 单臂研究 

分 类 号：R259[医药卫生—中西医结合]